Interaction of p-glycoprotein inhibitor-Verapamil- and Colchicine on some Neurobehavioral and Biochemical parameters in mice

Authors

  • Tayseer Shaker Mahmood 1 .Al-Hadi University College \ Nursing Department , Iraq
  • Raghdaa Dawood Obaid Al-Hadi University College \ Nursing Department , Iraq
  • Duraid Abdul-Hadi Abass University of Baghdad\Veterinary medicine collage\ Department of Physiology, Biochemistry & Pharmacology, Iraq

Keywords:

AchE activity, Creatinine kinase, neurobehavioral

Abstract

Neurobehavioral methods were used to investigate the effect of co-administration p-glycoprotein
inhibitor –verapamil- on colchicine –p-glycoprotein substrate given alone and in combination at low and
high therapeutic oral doses given daily for 3 months in (63) albino mice allocated to (7) equal groups 

References

Juliano , RL.; Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochemistry Biophysiology (1976). 455: p. 152-162.

Lin, J.H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Advance Drug Delivery. (2003). 55, p.53-81.

Moser,V.C.; Anthony,D.C.; Sette,W.F.; Macphial, R.C. Comparision of Sub-chronic Neurotoxicity of 2-hydroxymethyl acrylate and acrylamide in rat .Fundamental and Applied Toxicology , (1992).18:p.343-352.

Mohammed, F.K. and Omer, V.G. (1986). Behavioral and development effect in rat following utero exposure to 2, 4-d 12,4.5 mixture .Neurobehavioral. Toxicology and Teratology. 8: p.551-580

Mohammed ,F.K. (1984). Assessment of behavioral ,Neurochemical and development effect in developing rats following uterus exposure to non-mutagenic level of 2,4-d 12,4.5-t . Ph.D .thesis university of Missouri-Colombia, MO,USA.

Al-Backhoe, B. (2002). Neurobehavioral and biological changes induced by interaction of calcium and some insecticide in mice. PhD thesis, collage of veterinary medicine, Mosul university .Mosul , Iraq

Downloads

Published

2022-09-07

Issue

Vol. 8 (2022): TJABS

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

User Rights

Under the Creative Commons Attribution-NonCommercial 4.0 International (CC-BY-NC), the author (s) and users are free to share (copy, distribute and transmit the contribution).

Rights of Authors

Authors retain the following rights:
1. Copyright and other proprietary rights relating to the article, such as patent rights,
2. the right to use the substance of the article in future works, including lectures and books,
3. the right to reproduce the article for own purposes, provided the copies are not offered for sale,
4. the right to self-archive the article.

How to Cite

Interaction of p-glycoprotein inhibitor-Verapamil- and Colchicine on some Neurobehavioral and Biochemical parameters in mice. (2022). Texas Journal of Agriculture and Biological Sciences, 8, 36-43. https://zienjournals.com/index.php/tjabs/article/view/2368