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Abstract

The effect of glycyrrhizic acid derivatives (18-dehydroglyceric acid - 18 DGA, monoammonium salt of glycyrrhizic acid - MSGA) on the intensity of free radical processes during immobilization stress was studied. The experiments were performed on mature male rats with an initial weight of 165–185 g. Experimental groups of animals were formed taking into account body weight. The animals were divided into 4 groups of 6 each. The first group consisted of healthy animals, while the rats of the remaining groups were subjected to immobilization stress. In contrast, in animals treated with a monoammonium salt of glycerol acid, the number of rats with mucosal injury was reduced by 2 times, and the number of linear and fine-dot wounds by 15.3 and 57.7%, respectively. The number of wounded rats was 67% and the Pauls index decreased to 64.1%. We noted high gastro protective activity in a group of animals treated with 18- dehydroglyceric acid. Thus, the number of mucosal injuries in this group of animals decreased by 65.3%, and the number of spot injuries decreased by 71.8%. It is noteworthy that the number of linear erosions decreased by 36.6%. From the data in Table 2 in these groups, it can be seen that the number of rats with ulcers decreased by 45%.

Keywords

Peptic ulcer 18-dehydroglyceric acid monoammonium salt of glyceric acid Sel’e triad

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How to Cite
Khakimov Z.Z, Dzhanaev G.Yu, Mamadzhanova M.A, Mustanov T.B, & Kholmatov Zh.A. (2022). Effect of Derivatives of Glycyrrhetic Acid on The Intensity of Free Radical Processes During Immobilization Stress. Texas Journal of Medical Science, 8, 1–5. https://doi.org/10.62480/tjms.2022.vol8.pp1-5

References

  1. Zverev Ya.F. Flavanoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activity // Reviews on clinical pharmacology and drug therapy. 2017. Volume 15, No. 4. p. 5-13.
  2. Novikov V.E., Pozhilova E.V., Ilyukhin S.A. The effect of antihypoxants on the development of acute formalin edema. Reviews on Clinical Pharmacology and Drug Therapy. 2015. 13. №1. p. 41-44.
  3. Polukonova N.V., Novolokin N.A., Raikova S.V. and others. Anti-inflammatory, antipyretic and antimicrobial activity of a flavanoid-containing extract of Avranus medicinal (Gratiola officinalis L.) // Experimental and Clinical Pharmacology. 2015; volume 78; № 1; p. 34-38.
  4. Zakirov U.B., Azimov M.M., Radzhapova Sh.D. Anti-inflammatory activity of 3-amino - derivative of glycyrrhetic acid. Medical journal of Uzbekistan. 1988. № 1. p.61-64.
  5. Azizov U.M., Zakirov A.U., Zakirov Y.U., Sadikova Kh.U. Comparative study of the anti-inflammatory activity of glyderinin and glycyrram. Pharmaceutical Bulletin of Uzbekistan. 2016. №1. p.61-64.
  6. Allaeva, M. Z., Dzhanaev, G. Y., Khudoiberdiev, K. I., Mamadzhanova, M. A., & Mustanov, T. B. (2020). Influence of lesbochol dry extract on the current of experimental nervo-reflective gastric ultra. European Journal of Molecular and Clinical Medicine, 7(3), 2749-2753.
  7. Andreeva L.I., Kozhemyakin L.A., Kishkun A.A. Modification of the method for determining lipid peroxides in the test with thiobarbiturate acid // Laboratornoedelo. Moscow. 1988. № 11. p. 41-43.
  8. Mkhitaryan V.G., Badalyan G.E. Influence of peroxidized and non-peroxidized unsaturated fatty acids on the activity of superoxide dismutase // Journal of Experimental and Clinical Medicine. 1978. № 6. p.7-11.
  9. Determination of catalase activity / Karaluk M.A., Ivanova L.I., Mayorova I.G., Tokareva V.E. // Laboratory // 1988. № 1. p.16-19.
  10. Korsun V.F. and others // Phytotherapy for liver diseases. Herbs of Life. Centerpolygraph. Moscow. 2019.
  11. Shantanova L.N., Alekseeva E.A., Toropova A.A. and others. Stress-protective activity of the complex herbal remedy "Kardekaim" on the model of immobilization stress. We are experimenting with m clinic farmocol. 2015.Vol. 78 № 9. p.27-31.
  12. Shiretorova V.G. Anti-inflammatory activity of PinusSibirica Du Tour seed shell extract. Basic research. 2014. № 12. p. 352-354.
  13. Dyadyk A.I., Kugler T.E. Side effects of non-steroidal anti-inflammatory drugs // ConsiliumMedicum / 2017. 19 №12. p.94-99.
  14. Lapina T.L. Treatment of erosive and ulcerative lesions of the stomach and duodenum BC. Medical Review. 2021. № 4. p. 602-609.
  15. Mamajanova M.A. Influence of 18-dehydroglycyrrhetic acid on histomorphology in experimental ulcerative lesions of the gastric mucosa. Pharmaceutical Bulletin of Uzbekistan // 2016. № 3. p. 83-87.
  16. Ayala A., Munoz M. F., Arguelles S. Lipid peroxidation. Production, Metabolism and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenel // Oxidative Medicine and cellular Longevity. 2014. Article ID 360438, 31 P.
  17. Rahman Kh. Studies on free radicals, antioxidants and co-factors // ClinInterv Aging. 2007 Jun. 2 №2. p. 219-236.

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