Texas Journal of Medical Science provides the opportunity to the authors to publish their original research articles in Medical Sciences and allied field. Frequency of Publication: Monthly Acceptance Notification: 45 Days ISSN (Online): 2770-2936 doi Prefix: 10.62480
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Myocardial Dystrophy In Chronic Obstructive Pulmonary Disease: Mechanisms Of Development, Early Markers, And Treatment Approaches
This article examines the relationship between chronic obstructive pulmonary disease (COPD) and myocardial dystrophy, focusing on pathophysiological mechanisms, diagnostic approaches, and therapeutic strategies. A total of 120 COPD patients were evaluated for myocardial dysfunction using echocardiography, cardiac biomarkers (NT-proBNP, troponin I, CK-MB), and inflammatory markers (IL6, TNF-α, CRP). The results demonstrated that myocardial dystrophy is present in 68.3% of COPD patients, with severity correlating with disease stage. Hypoxia-driven oxidative stress and systemic inflammation were identified as the primary mechanisms. Combined bronchodilator therapy supplemented with cardioprotective agents (trimetazidine 35 mg twice daily) significantly improved both pulmonary and cardiac functional parameters.
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The Role of Comorbidities in the Development of Bronchopulmonary Diseases in Military Personnel
This study investigates the role of comorbidities in the course of bronchopulmonary diseases among military personnel. Comorbid conditions were identified in 59.3% of patients. The most common were gastrointestinal diseases (37.7%), cardiovascular diseases (10.6%), kidney diseases (7.7%), and diabetes mellitus (3.3%). Cardiovascular diseases (OR=19.6; p
bronchopulmonary diseasesmilitary personnel
POST-COVID Lipid Profile Alterations In Stage 3 Chronic Kidney Disease Patients
The study evaluated changes in renal functional status in patients with stage 3 chronic kidney disease (CKD) who had previously experienced COVID-19 infection. A total of 131 patients were included in the study: • Group 1 — CKD stage 3 (n=70); • Group 2 — CKD stage 3 + COVID-19 (n=61). For each patient, the lipid profile was evaluated, including: Total cholesterol (TC, mmol/L), Triglycerides (TG, mmol/L), Low-density lipoprotein cholesterol (LDL-C, mmol/L), High-density lipoprotein cholesterol (HDL-C, mmol/L) Laboratory measurements were performed at 1 month and 3 months. Data are presented as mean ± SEM. Statistical analysis was conducted using Student’s t-test or appropriate parametric tests. Significant changes over the 3-month period were indicated with an asterisk (*), p
Prevalence Of The Ppargc1a Gene Gly482ser Polymorphism In Women With Obesity
In recent years, according to leading scientists, a hereditary predisposition to obesity has been identified. Various mutations that significantly affect energy metabolism and adipose tissue proliferation can lead to the development of obesity, but in most patients they are not detected. This article presents the results of research on proving the prevalence of the PPARGC1A gene polymorphism in Uzbek women of childbearing age with obesity and creating the necessary conditions for determining the potential goals of drug therapy and developing personalized effective approaches to the diagnosis, treatment, and prevention of obesity.
Changes In Biochemical And Cytokine Markers Of The Liver In The Acute Period Of Combined Facial Trauma
This article presents the results of an assessment of the functional state of the liver in patients with concomitant facial bone injuries. The study included 58 patients treated at the Andijan branch of the Russian Scientific Center for Emergency Medicine. Blood biochemical parameters reflecting inflammatory activity, protein-synthetic function of the liver, and the degree of cytolysis ( procalcitonin , total protein, albumin, ALT , and AST ) were assessed dynamically from admission to the seventh day. It was found that in the first hours after injury, a pronounced activation of the systemic inflammatory response and cytolytic syndrome is observed: a significant increase in procalcitonin , increased transaminase activity, and a decrease in protein fractions. By the fifth and seventh days, these parameters gradually normalize, indicating the restoration of metabolic liver function and the effectiveness of the therapy
Nazhmiddinov Bokhodirzhon Bakhritdin ugli
Correlation Of The Functional State Of The Liver And The Severity Of Patients In The Complex Treatment Of Combined Facial Bone Trauma
The study comprehensively assessed the relationship between the severity of patients' general condition and liver function in patients with concomitant facial bone injuries. Biochemical and oxidative parameters were analyzed in 122 patients using clinical data, international severity assessment scales (ISS, GCS, PTS, PELOD), and laboratory test results. It was found that the severity of systemic inflammation and cytolysis, decreased protein-synthetic function of the liver, and impaired coagulation status correlated with the severity of traumatic injury. Patients receiving hepatoprotective therapy demonstrated more favorable dynamics of these parameters and more rapid clinical improvement. The obtained data confirm the significance of liver markers as prognostic criteria and emphasize the role of liver function correction in the comprehensive treatment of concomitant facial bone injuries
Bone and bone-substituting materials in plastic surgery of oroantral perforations of the maxillary sinus.
Oroantral perforations (OAP) and fistulas are common complications of maxillary tooth extraction and lateral alveolar surgery. Soft tissue closure of the defect does not always ensure restoration of bone volume, which is important for subsequent implant rehabilitation. The aim of this review was to analyze the use of bone and bone-substituting materials in OAP repair, taking into account morphological healing mechanisms and postoperative rehabilitation. An analysis of domestic and international publications on the use of autogenous bone grafts, allogeneic and xenogeneic osteoplastic materials, collagen membranes, and combined composites for the closure of maxillary sinus floor defects was conducted. It was shown that the use of bone or bonesubstituting materials helps maintain alveolar bone height, improve the quality of the regenerated bone, and promote the formation of a complete bone structure, which is morphologically associated with accelerated osteoconduction and angiogenesis. The choice of material determines the rehabilitation strategy and the timing of subsequent implantation
Dynamics of Clinical, Laboratory, and Morphostructural Parameters in Patients with Infected Pancreatic Necrosis Associated with Diabetes Mellitus
In this article, the authors analyze the dynamics of clinical, laboratory, and morphostructural parameters in patients with infected pancreatic necrosis (IPN) associated with diabetes mellitus (DM). Clinical studies were conducted in 62 patients with IPN and concomitant DM. The significance of clinical signs, laboratory parameters, instrumental diagnostic methods, and morphostructural indicators in patients with IPN associated with DM was evaluated. Overall, the authors conclude that a comprehensive assessment of clinical, laboratory, and morphostructural changes in patients with IPN and concomitant DM is accompanied by an increasing systemic inflammatory response, pronounced organ dysfunction, and progression of destructive foci during the first 1-3 days of the disease, followed by partial stabilization of the patients' condition by the 10th day as a result of ongoing comprehensive treatment. The study demonstrated that conventional therapeutic approaches do not ensure timely prevention of disease progression in patients with IPN associated with DM
Morphological Characteristics, Histogenesis, And Differential Diagnosis Principles of Cardiac Myxoma
To analyze the pathomorphological and immunohistochemical characteristics, as well as modern aspects of the histogenesis of cardiac myxoma, and to systematize the criteria for differential diagnosis with other intracardiac formations.
Echocardiography: Current Problems and Prospects in Modern Diagnostics
This article analyzes modern problems in the practice of echocardiography (EchoCG), which is the primary method in the non-invasive diagnosis of cardiovascular diseases. The dependence of image quality on the patient's constitution, subjectivity in measurements (human factor), as well as issues of standardization of new technologies such as 3D EchoCG and Speckle Tracking are highlighted. The role and prospects of artificial intelligence (AI) technologies in overcoming these problems are evaluated.
Associate,Dosent Tashkent State University of Economics, Department of Uzbek and Russian Languages
Nasal breathing disorders are increasingly recognized as serious health concerns in the pediatric population. Recent research points to a robust connection between compromised nasal airflow and a variety of cognitive deficits in children. Persistent mouth breathing associated with nasal obstruction often results in altered craniofacial development and impacts sleep quality, which in turn can disrupt optimal brain maturation and neurocognitive functioning. This paper discusses the importance of monitoring cognitive functions in children affected by nasal breathing disorders, the neurobiological mechanisms linking respiratory impairment and cognitive deficits, available assessment methods, and evidence-based interventions. Special attention is given to the challenges in early detection, the role of multidisciplinary collaboration, and the implications for long-term developmental and academic outcomes.
Headache As A Manifestation Of Paranasal Sinus Diseases: The Significance Of Plain Radiography
The prevalence of inflammatory diseases of the paranasal sinuses (PNS) remains consistently high, despite the introduction of modern diagnostic and treatment methods. This pathology occupies a significant place in the structure of outpatient visits to otorhinolaryngologists. In several regions, a particularly high incidence of sinusitis is observed; this is attributed to adverse environmental conditions, exposure to industrial factors, and the development of secondary immunodeficiency states within the population
Comparative Analysis Of Quality-Of-Life Indicators After Total And Subtotal Thyroidectomy
Surgical treatment of thyroid diseases remains one of the main therapeutic approaches, while the choice of surgical extent (total or subtotal thyroidectomy) influences postoperative outcomes and patients’ quality of life. The aim of this study was to perform a comparative analysis of quality of life indicators following total and subtotal thyroidectomy. A prospective study involving 140 patients was conducted. Quality of life was assessed using the ThyPRO questionnaire. No statistically significant differences in the overall quality of life between the groups were identified (p>0.05); however, symptoms of hypothyroidism were more frequently observed after total thyroidectomy, whereas anxiety related to the risk of recurrence was more common after subtotal thyroidectomy. The incidence of hypoparathyroidism reached up to 22%, and transient recurrent laryngeal nerve paresis was observed in approximately 6.5% of cases. The obtained data confirm the comparability of these surgical methods despite differences in certain clinical aspects.
The Importance Of Proteins And Protein-Containing Medicinal Products In Medicine
This article analyzes the biological and physiological significance of proteins, their main functions in the human body, as well as protein-based drugs and their fields of application in medicine. Proteins are the principal structural components of every living cell and play an essential role in metabolism, immune defense, enzymatic processes, and the maintenance of cellular integrity. The article also provides a broad overview of pathological conditions associated with proteins and the medical need for protein substances in clinical practice. It serves to strengthen theoretical knowledge and foster clinical thinking among students studying in the field of medicine
Sovremennye Cojnye Meniteli I Kananeinjenernye Construction And Reconstruction Of Cojnyx Defects In The Maxillofacial Area
Restoration of the jaw defect in the maxillofacial region remains one of the most common types of reconstructive surgery due to the combination of high functional and aesthetic requirements. Traditional methods ( autodermoplasty , loskutnye operatsii) have a limited volume of donor tissue, risk of donor morbidity and expressed rubtsevaniem. Development of kojnyx zameniteley and tissue engineering construction (TIK) has opened up new possibilities for the regeneration of kojnyx cover skins, including the use of biopolymer matrices, cellular transplants, mesenchymal stem cells, and also technological 3Dbioprinting
Supporting clinical decisions through artificial intelligencebased biomarker analysis and finite material modeling for non-invasive maxillofacial bone regeneration using BTCP/PLLA scaffolds
Maxillofacial bone regeneration remains a critical challenge in reconstructive surgery, where the integration of bioresorbable scaffolds such as B-TCP/PLLA (beta-tricalcium phosphate/poly-L-lactic acid) has shown promising osteoconductive and osteoinductive properties. In this study, we developed a comprehensive clinical decision support framework that combines finite element modeling (FEM) and machine learning-driven biomarker analysis to evaluate bone healing in patients treated with B-TCP/PLLA scaffolds. Quantitative biomarkers, including alkaline phosphatase (ALP), vascular endothelial growth factor (VEGF), and runt-related transcription factor 2 (Runx2), were collected at multiple postoperative intervals and processed using supervised learning algorithms such as Random Forest and Support Vector Machine (SVM). Our FEM simulations provided insight into stress distribution and scaffold integration, supporting the prediction of ossification patterns. Results show a strong correlation between computational stress models and biomarker expression levels, with the predictive model achieving an AUC of 0.91, precision of 0.88, and recall of 0.85. These findings underscore the potential of combining biomechanical modeling with molecular profiling to enhance postoperative monitoring and early prediction of bone regeneration outcomes. The proposed system offers a novel, data-driven approach for personalized treatment planning and real-time clinical support, contributing to the development of next-generation AIassisted healthcare tools in maxillofacial surgery.
Algorithms for extracting the QRS complex from the ECG
ECG is a diagnostic signal recorded on the patient's body at standard electrode locations, which reflects the electrical activity of the heart muscle. One of the main features of the ECG is a pulse waveform called the QRS complex. This complex corresponds to the time of depolarization of the heart ventricles and is of important diagnostic importance.
This article provides a scientific analysis of reproductive health problems in women, their causes, risk factors, and impact on overall health. Reproductive health is closely related to a woman’s general wellbeing, and its disorders are manifested through various gynecological conditions, including menstrual cycle disorders, infertility, inflammatory diseases, and hormonal imbalance. The article also highlights the role of social, environmental, and occupational factors in the development of these issues. The study examines preventive measures, modern diagnostic methods, and the importance of a healthy lifestyle in maintaining women’s reproductive health. Based on the findings, practical recommendations have been developed
Analysis of the relationship between hemodynamic parameters and markers of renal dysfunction, Klotho protein, vitamin D, and parathyroid hormone in hypertension
Globally, targeted scientific research is being conducted aimed at a deeper study of the origin and pathogenesis of renal dysfunction (RD), determining the role of Klotho protein in the mechanism of its development. This protein plays an important role in kidney function and the vascular system. A decrease in the amount of Klotho protein intensifies the pathological process in these systems. This study examines the relationship between Klotho protein and RD development.
Brain Neuroplasticity in Students Under Conditions of Intensive Learning: Molecular and Cellular Mechanisms
The objective of the present study is to systematize current knowledge regarding the specific molecular, cellular, and systemic mechanisms of neuroplasticity activated in the brains of students during periods of intensive learning, as well as to identify the endogenous and exogenous factors that modulate the efficacy of these processes
Laparoscopy In The Diagnosis Of Acute Surgical Diseases Of The Abdominal Organs
The article presents an analysis of the results of using diagnostic laparoscopy in 47 patients with suspected acute surgical pathology of the abdominal organs from 2020 to 2025. The author emphasizes the high informative value of the method, which allows for diagnostic verification and determination of treatment tactics with minimal trauma. Particular attention is paid to the diagnosis of acute appendicitis, including the use of the Krieger technique to identify catarrhal forms. The study proves that the implementation of laparoscopy significantly reduces the number of "unjustified" appendectomies and avoids diagnostic errors, the frequency of which reaches 30% with the traditional approach
Clinical Efficacy Of Diagnostic Laparoscopy In Abdominal Trauma
The article examines the clinical efficacy of diagnostic laparoscopy in abdominal trauma. Based on the analysis of 129 patients treated at the clinic of Tashkent State Medical University from 2023 to 2025, it was demonstrated that laparoscopy is the most informative minimally invasive method in cases of unclear clinical presentation. The authors developed and substantiated specific indications for this procedure, including the dynamics of pain syndrome, the presence of free fluid detected by ultrasound, and changes in hemodynamic parameters. The use of this technique allows timely identification of internal organ injuries and significantly reduces the number of unnecessary exploratory laparotomies.
Epidemiological Analysis Of Breast Cancer And The Effectiveness Of Radiation And Chemotherapy
This article The article presents a clinical and epidemiological analysis of breast cancer (BC) among women in the Fergana region, assessing the prevalence of the disease, the effectiveness of radiation and chemotherapy, as well as the frequency and nature of therapeutic consequences. This study used data from 382 patients treated at the Fergana Regional Branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology from 2020 to 2024. Radiation therapy demonstrates a higher survival rate (76.4%), which is explained by its use primarily in stages I and II, local tumor control, and a reduced risk of recurrence. Chemotherapy (72.1%) is used more often in stage III, HER2+, and triplenegative forms. Therefore, a slight decrease in survival is explained by the initially more severe clinical profile of the group, rather than by the lower efficacy of the method. Key prognostic factors, survival rates, and the frequency of side effects of therapy are identified.
Aspects Of Regional-Specific Characterization Of The Epidemiology And Risk Of Major Non-Communicable Diseases In The Adult Rural Population Of Andizhan
Major chronic non-communicable diseases (cardiovascular diseases, tumors, chronic respiratory diseases) have been among the most widespread diseases in the world for the past few years, and they remain the leading object of science and practice as the main cause of the therapeutic continuum among the population. Therefore, in the current era, preventive and prophylactic medicine, both theoretically and practically, and primarily in relation to major non-communicable diseases, has become an urgent issue and a necessity. According to the World Health Organization, "the annual mortality rate from them is 71%, and economic losses are about 1 trillion per year..." In the world, special attention is paid to epidemiological scientific research aimed at identifying the regional characteristics of the occurrence of major non-communicable diseases and creating and improving measures for the prevention of their various forms. In particular, the introduction of methods for early detection and prediction of the risk of developing major non-communicable diseases based on “…epidemiological markers” - risk factors, in populations with different characteristics is identified as one of the important tasks. At the same time, scientific research is also actively underway, including in Uzbekistan, to accurately and objectively assess the epidemiological and clinical processes in non-communicable diseases, to improve predictive algorithms - models, taking into account the territorial course of diseases and the “accumulation of risk factors”. However, despite the great achievements of medical science, there is no generally accepted methodology for the prevention of major non-communicable diseases. Western medicine believes that the outcome of prevention (population health) is 50% related to living conditions and lifestyle, 20% to environmental conditions, 20% to genetic factors, and 10% to the healthcare system. Eastern medicine believes that the outcome of prevention is 70% related to thinking, 20% to lifestyle, and 10% to nutrition.
Organization Of Monitoring The Quality Of Services Provided To Prevent And Combat Postpartum Bleeding In Women
This article describes how to monitor the quality of care for women during pregnancy and childbirth for postpartum haemorrhage, evaluate the clinical and cost-effectiveness of care, standard requirements, and conduct surveys, patient reviews and prioritize complaints and appeals. . feedback on patient satisfaction monitoring
The Effect Of Proton Pump Inhibitors On The Development Of Hepatic Encephalopathy
The most common complications associated with cirrhosis are neurological and neuropsychiatric disorders, referred to as hepatic encephalopathy (HE). Proton pump inhibitors (PPI) cannot be without risk, as recent studies have shown a clear link between PPI and conditions such as encephalopathy. IPP work by suppressing acid, which can disrupt intestinal microbiomes. Patients with cirrhosis are at risk of developing hepatic encephalopathy (HE), mainly due to the ammonia produced by the typical intestinal flora, and may subsequently be at risk of changes in this condition if the microbiome changes in any way.
Abdurashidov Samariddin Abdurakhmonovich.
Asthma attack is a severe and life-threatening condition of bronchial asthma, manifesting in children as acute difficulty in breathing. The disease primarily occurs due to inflammation of the bronchial mucosa, bronchospasm, and increased mucus production. Symptoms include shortness of breath, coughing, chest tightness, and fainting. Asthma attacks require urgent medical attention because delays can lead to oxygen deficiency and life-threatening complications in children. Prevention involves proper management of bronchial asthma, avoiding allergens, and correct use of inhalers and bronchodilator medications
Cytokine Regulation In Pubertal Girls With Opsomenorrhea Across Different Body Mass Index Categories
Menstrual rhythm disturbances during puberty often reflect a combination of neuroendocrine immaturity and early forms of ovulatory dysfunction. In the context of abnormal body weight, inflammatory mechanisms may serve as an additional factor modulating reproductive regulation
Subclinical Myocardial Dysfunction In Patients With Arterial Hypertension With And Without Type 2 Diabetes Mellitus And Diabetic Nephropathy: A Speckle-Tracking Echocardiography Study
Arterial hypertension (HTN) and type 2 diabetes mellitus (T2DM) are major contributors to cardiovascular morbidity and frequently coexist, leading to accelerated myocardial remodeling and heart failure development. Diabetic nephropathy (DN) further aggravates cardiorenal interactions, even in the absence of overt heart failure. Conventional echocardiographic parameters may remain normal during early disease stages, delaying diagnosis of myocardial dysfunction. Objective. To compare subclinical myocardial dysfunction among patients with arterial hypertension alone, arterial hypertension with type 2 diabetes mellitus, and arterial hypertension with type 2 diabetes mellitus complicated by diabetic nephropathy using global longitudinal strain (GLS) and mechanical dispersion (MD). Methods. A total of 120 patients were enrolled and divided into three groups: HTN (n=40), HTN+T2DM (n=40), and HTN+T2DM+DN (n=40). All patients underwent clinical evaluation, laboratory testing, electrocardiography, and transthoracic echocardiography with speckle-tracking analysis. GLS and MD were compared between groups. Results. Left ventricular ejection fraction was preserved in all groups. GLS progressively worsened from HTN to HTN+T2DM and HTN+T2DM+DN groups (−18.9 ± 1.8%, −16.7 ± 2.1%, −14.8 ± 2.4%, respectively; p
Acute Kidney Injury In Children: Diagnostic Challenges And Treatment Outcomes At A Regional Pediatric Hospital
Acute kidney injury (AKI) in children remains a significant cause of morbidity and mortality, particularly in resource-limited regional hospitals. This prospective observational study evaluated 74 pediatric patients with AKI admitted to the Fergana Region’s Multi-Specialty Children’s Hospital between January 2022 and June 2025. The leading etiologies included sepsis, dehydration, cardiac surgery complications, and nephrotoxic drug exposure. Most patients (79.7%) were managed conservatively, while 20.3% required renal replacement therapy, primarily peritoneal dialysis. At discharge, 60.8% achieved complete recovery, 24.3% had partial recovery, 9.5% progressed to chronic kidney disease, and 5.4% died. These outcomes demonstrate both the potential for recovery with timely intervention and the persistent risk of poor prognosis in a subset of patients. Early recognition, standardized monitoring, nephrotoxin stewardship, and capacity building in peritoneal dialysis are essential strategies to improve pediatric AKI outcomes in regional settings.