##plugins.themes.academic_pro.article.sidebar##

Download
pdf

##plugins.themes.academic_pro.article.main##

Abstract

Autoantibodies damage and weaken joints in rheumatoid arthritis (RA), an autoimmune condition. Leukocyte (Monocyte, Lymphocyte, Mast Cell, etc.) infiltrations into the synovial compartment that cause inflammation in the synovial membrane are characteristics of RA. This study's objectives were to measure the levels of IL-6 and IL-17 in the serum in a sample of RA patients and to examine the relationship between those levels and a variety of clinical outcomes. It included fifty (50) rheumatoid arthritis patients of both sexes. They are taken from hospitals and clinics, and their ages range from (31 to) 79. The control group consists of (40) people who appear normal. The concentration of IL-6 in serum has been determined using the ELISA enzyme-linked immuno-sorbent test. The findings indicated that men have a higher prevalence of sickness than women. 30% for females against 70% for males. Regarding the age distribution of the patients, they were between the ages of 31 and 79, with a median age of 55. Compared to healthy individuals, who had an interleukin-6 concentration of 139.8– 165.88 pg/ml, the concentration in the study participants was 217.1–152.6 pg/ml. Interleukin 17 was present in patients at an average concentration of 129.19 36.88 pg/ml as opposed to 61.62 16.75 pg/ml in healthy individuals.

Keywords

Rheumatoid arthritis IL-17 IL-6 RA

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite
Rawaa Najim Alkhamessi. (2023). Evaluation of Some Interleukins Levels of Rheumatoid Arthritis (RA) in Baghdad province / Iraq. Texas Journal of Agriculture and Biological Sciences, 14, 7–10. Retrieved from https://zienjournals.com/index.php/tjabs/article/view/3473

References

  1. Akchurin OM., Kaskel F (2015). Update on Inflammation in Chronic Kidney Disease. Blood purification.; 39:84–92
  2. Al-quraishi GMS (2015). The role of Interleukin -18 / Interleukin -18 Binding Protein in Rheumatoid Arthritis patients, Iraqi Journal of Science.; 942 :51-56.
  3. Bridgewood C, Alase A, Watad A, (2019). The IL23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man. Inflamm Res.; 68(6): 423-426.
  4. Chen Z, Bozec A, Ramming A, (2019). Antiinflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat Rev Rheumatol.; 15(1): 9-17.
  5. Chen Z, Bozec A, Ramming A, Schett G. (2019). Anti- inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nature Reviews Rheumatology.; 15(1): 9-17.
  6. Ecoeur F, Weiss J, Schleeger S, (2020). Lack of evidence for expression and function of IL-39 in human immune cells. PLoS One.; 15(12): e0242329.
  7. Elhewala A, Soliman SG, Labib AA, Mousa WA, Salah D. (2015). Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity, a clinical and ultrasound study. Egypt Rheumatol Rehabil.; 42: 183-187.
  8. Elshabrawy HA, Chen Z, Volin MV, Ravella S, Virupannavar S, Shahrara S. (2015). The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis.; 18(4): 433-448.
  9. Guan SY, Leng RX, Khan MI, (2017). Interleukin35: a Potential Therapeutic Agent for Autoimmune Diseases. Inflammation.; 40(1): 303-310.
  10. Kany S, Vollrath JT, Relja B (2019). Cytokines in Inflammatory Disease. Int J Mol Sci.; 20(23): 6008.
  11. Li Y, Jie Y, Wang X,(2021). Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1/Th2/Th17-related cytokines. BMC Immunol.; 22(1): 42
  12. Li Y, Yao L, Liu S,(2019). Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity. J Investig Med.; 67(3): 707- 710.
  13. Luo Y, Liu F, Liu H, (2017). Elevated serum IL-39 in patients with ST-segment elevation myocardial infarction was related with left ventricular systolic dysfunction. Biomark Med.; 11(6): 419-426.
  14. Mirlekar B, Pylayeva-Gupta Y (2021). IL-12 Family Cytokines in Cancer and Immunotherapy. Cancers (Basel).; 13(2): 167.
  15. Robert M, Miossec P. (2019). IL-17 in rheumatoid arthritis and precision medicine: from synovitis expression to circulating bioactive levels. Frontiers in medicine.; 5: 364.
  16. Schulz M., Dotzlaw H., Neeck G (2014). Ankylosing Spondylitis and Rheumatoid Arthritis: Serum Levels of TNF- and Its Soluble Receptors during the Course of Therapy with Etanercept and Infliximab. BioMed Res Int.;2014:1-7.
  17. Ting-yan Xu., Yi Zhang., Yan Li1., Ding-liang Zhu., Ping-jin Gao (2014). The association of serum inflammatory biomarkers with chronic kidney disease in hypertensive patients. Renal Failure.; 36(5):666–672.
  18. Wang W, (2015). Effects of serum creatinine calibration on estimated renal function in african americans: the Jackson heart study. American j Medical Sciences. ; 349 (5) :379-384.
  19. Wang X, Zhang Y, Wang Z, (2018). Anti IL 39 (IL 23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus like mice. Mol Med Rep.; 17(1): 1660-1666.
  20. Xiao H, Alisic H, Reiman BT, (2021). IL-39 Reduces Proliferation and Promotes Apoptosis of Bladder Cancer by Altering the Activity of Cyclin E and Fas. Anticancer Res.; 41(5): 2239-2245.
  21. Xin PL, Jie LF and Cheng Q,(2021). Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis. Front Pharmacol.; 12: 655114.
  22. Yang MG, Tian S, Zhang Q, (2020). Elevated serum interleukin-39 levels in patients with neuromyelitis optica spectrum disorders correlated with disease severity. Mult Scler Relat Disord.; 46: 102430.
  23. Zhair KH, Kuba RH, abdulhussain JY (2016). Effects of Methotrexate and Etanercept on C-Reactive Protein and Anti-Cyclic Citrullinated Peptide Antibodies Level in Rheumatoid Arthritis Patients. Al-Kufa University Journal for Biology, (Special Second International Scientific Conference for the Life Sciences).; 120-124