The Effect Of Proton Pump Inhibitors On The Development Of Hepatic Encephalopathy

Authors

  • Boltayev Anvar Ismailovich Payarik College of Public Health named after Abu Ali ibn Sina.
  • Adilova Sozhida Khurramovna Payarik College of Public Health named after Abu Ali ibn Sina.
  • Zhozilova Nigora Mamadalievna Payarik College of Public Health named after Abu Ali ibn Sina.
  • Raimov Tolib Vakhobbidinovich Payarik College of Public Health named after Abu Ali ibn Sina.
  • Utkirov Elmurod Utkirovich Payarik College of Public Health named after Abu Ali ibn Sina.
  • Akbaev Abdulla Bakhriddinovich Payarik College of Public Health named after Abu Ali ibn Sina.
  • Abdurashidov Samariddin Abdurakhmonovich. Payarik College of Public Health named after Abu Ali ibn Sina.

DOI:

https://doi.org/10.62480/tjms.2026.vol53.pp9-12

Keywords:

Liver cirrhosis, hepatic encephalopathy, proton pump inhibitors

Abstract

The most common complications associated with cirrhosis are neurological and neuropsychiatric disorders, referred to as hepatic encephalopathy (HE). Proton pump inhibitors (PPI) cannot be without risk, as recent studies have shown a clear link between PPI and conditions such as encephalopathy. IPP work by suppressing acid, which can disrupt intestinal microbiomes. Patients with cirrhosis are at risk of developing hepatic encephalopathy (HE), mainly due to the ammonia produced by the typical intestinal flora, and may subsequently be at risk of changes in this condition if the microbiome changes in any way.

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Published

2026-02-18

Issue

Vol. 53 (2026): TJMS

Section

Articles

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How to Cite

The Effect Of Proton Pump Inhibitors On The Development Of Hepatic Encephalopathy. (2026). Texas Journal of Medical Science, 53, 9-12. https://doi.org/10.62480/tjms.2026.vol53.pp9-12