Morpho-Functional Changes Of The Kidneys In Hypoparathyroidism: A Comprehensive Review
DOI:
https://doi.org/10.62480/tjms.2025.vol50.pp58-63Keywords:
hypoparathyroidism, renal morphology, nephrocalcinosisAbstract
Hypoparathyroidism (HPT) is a rare endocrine disorder characterized by chronic parathyroid hormone (PTH) deficiency, resulting in persistent hypocalcemia, hyperphosphatemia, and reduced calcitriol synthesis. These biochemical abnormalities have a profound impact on renal morphology and function. Numerous studies indicate that long-standing HPT predisposes patients to nephrocalcinosis, nephrolithiasis, tubular injury, interstitial fibrosis, and a progressive decline in glomerular filtration rate. Despite increasing recognition of renal involvement, comprehensive evaluation of morpho-functional kidney changes in HPT remains limited
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