The Significance Of The Arg223gln Lepr Gene Polymorphism In Obesity
DOI:
https://doi.org/10.62480/tjms.2025.vol49.pp20-24Keywords:
women of childbearing age, metabolically healthy obesity, metabolically complicated obesityAbstract
Currently, the role of genetic factors in the development of various obesity phenotypes in individuals of different races, ethnicities, and genders is of particular interest. In particular, given the high prevalence of obesity among Uzbek women of childbearing age, studying the characteristics and genetic underpinnings of the various phenotypes of this pathology is of great importance. The action of one of the main obesity hormones, leptin, is controlled by the expression of leptin receptors, which are encoded by the LEPR gene. Mutations in this gene lead to increased leptin levels, decreased expression of the receptors that mediate its action, or altered leptin specificity, leading to the development of leptin resistance. Therefore, studying the allele and genotype frequencies of the ARG223GLN polymorphism of the LEPR gene is of great importance for the early detection and prevention of obesity in this patient population. This article examines and analyzes the prevalence of alleles and genotypes of the ARG223GLN polymorphism in the LEPR gene across various obesity phenotypes.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
User Rights
Under the Creative Commons Attribution-NonCommercial 4.0 International (CC-BY-NC), the author (s) and users are free to share (copy, distribute and transmit the contribution).
Rights of Authors
Authors retain the following rights:
1. Copyright and other proprietary rights relating to the article, such as patent rights,
2. the right to use the substance of the article in future works, including lectures and books,
3. the right to reproduce the article for own purposes, provided the copies are not offered for sale,
4. the right to self-archive the article.
