Clinical And Morphological Features In Diffuse Forms Of Breast Cancer: Results Of Digital Morphometry

Authors

  • Yigitaliyev Alisher Bakhodir ugli Assistant of the Department of Urology and Oncology of the Fergana Medical Institute of Public Health
  • Tursunov Khasan Ziyayevich Head of the Department of Pathological Anatomy of Tashkent State Medical University, Doctor of Medical Sciences, Professor
  • Gafur-Okhunov Mirza-Ali Aliyarovich Head of the Department of Oncology of the Center for the Development of Professional Qualifications of Medical Workers, Doctor of Medical Sciences, Professor
  • Akhrayeva Dilnoza Bakhtiyarovna Assistant of the Department of Oncology of the Center for the Development of Professional Qualifications of Medical Workers, PhD

DOI:

https://doi.org/10.62480/tjms.2025.vol49.pp14-19

Keywords:

breast cancer, diffuse forms, ductal invasive carcinoma

Abstract

In the study, tissue and cellular changes in diffuse forms of breast cancer (ductal, lobular, and inflammatory variants) were assessed using digital morphometry. Biopsy materials were scanned in the NanoZoomer system and analyzed using the QuPath and ImageJ/Image Pro Max programs. The main indicators were the proportion of stroma, excretory ducts, blood vessels, lobes, and the nuclear-cytoplasmic index (NCI). According to the results, in the ductal variant, the proportion of stroma and excretory ducts increased, the lobules shortened, and the ALS decreased to 0.69. In the lobar variant, parenchyma predominates and angiogenesis increases (LAS - 0.61), and in the inflammatory form, vascular-inflammatory changes predominate. In conclusion, digital morphometry is an effective method for differentiating diffuse phenotypes, assessing the level of cellular dedifferentiation and angiogenesis. The obtained indicators are recommended as an important prognostic criterion for making a clinical decision and determining the therapeutic orientation in breast cancer.

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Published

2025-10-08

Issue

Vol. 49 (2025): TJMS

Section

Articles

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How to Cite

Clinical And Morphological Features In Diffuse Forms Of Breast Cancer: Results Of Digital Morphometry. (2025). Texas Journal of Medical Science, 49, 14-19. https://doi.org/10.62480/tjms.2025.vol49.pp14-19