##plugins.themes.academic_pro.article.main##

Abstract

The article presents information about the study of the features of the course of pneumonia in children, changes in the hemostasis system, features of genetic polymorphism in various inflammatory diseases. An acute inflammatory process in the lungs leads to a violation of their metabolic function, disrupts the balance of the hemostasis system of the lungs. According to the results of laboratory and instrumental examination in children with pneumonia, significant changes in the hemostasis system were revealed

Keywords

children pneumonia hemostasis genetic polymorphism

##plugins.themes.academic_pro.article.details##

How to Cite
Bobomuratov T. A, Fayziev N. N, & Mallaev Sh. Sh. (2023). Genetic Characteristics of the Hemostasis System in Early Children with Pneumonia. Texas Journal of Medical Science, 23, 1–4. https://doi.org/10.62480/tjms.2023.vol23.pp1-4

References

  1. Parpugga, T.K. et al. The effect of PAI-1 4G/5G polymorphism and clinical factors on coronary artery occlusion in myocardial infarction // Dis. markers. [Electronic resource] - 2015. - Access mode: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529953//, free. - Zagl. from the screen. – Screen text English.].
  2. Ye, Z. et al. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls // Lancet. - 2006. - Vol. 367, No. 9511. - R. 651-658.
  3. Martinelli, N. et al. Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis // PLoS one. - 2008. - Vol. 3, #2. – e1523.
  4. Kathiresan, S. et al. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk // Arterioscler. thromb. vasc. biol. - 2006. - Vol. 26, no. 6. - R. 1405-1412.
  5. Danesh, J. et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analy- sis // JA 6. Mannila, M.N. et al. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction // Thromb. haemost. – 2005. – Vol. 93, №3. – Р. 570–577.
  6. Agirbasli, M. et al. Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease // Eur. j. cardiovasc. prev. rehabil. 2011. – Vol. 18, №6. – Р. 803–809.
  7. Lima, L.M. et al. PAI-1 4G/5G polymorphism and plasma levels association in patients with coronary artery disease // Arq. bras. cardiol. – 2011. – Vol. 97, №6. – Р. 462–389.
  8. Ploplis, V. A. Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease // Current drug targets. – 2011. – Vol. 12, №12. – Р. 1782–1789.
  9. Mannucci, P.M. et al. The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease // J. thromb. haem. – 2010. – Vol. 8, №10. – Р. 2116– 2121.
  10. Desch, K.C. et al. Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association // Proc. natl. acad. sci. USA. – 2013. – Vol. 110, №2. – Р 588–593.
  11. Van Schie, M. et al. Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review // J. thromb. haemost. –2011. – Vol. 9, №5. – Р. 899–908.
  12. Van Schie, M.C. et al. Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease // Blood. 2011. – Vol. 117, №4. – Р. 1393–1399.
  13. Tang, W. et al. Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans // Am. j. hematol. – 2015.– Vol. 90, №6. – Р. 534–540.
  14. Rivera-García, B.E. et al. Platelet glycoprotein IIIA PLA1/A2 polymorphism in young patients with ST elevation myocardial infarction and idiopathic ischemic stroke // Mol. cell. biochem. – 2013. – Vol. 384, Issue 1. – P. 163–171.
  15. Boekholdt, S.M. et al. Interaction between a genet 32. Kucharska-Newton, A.M. et al. Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaquemorphology: the Atherosclerosis Risk in Communities (ARIC) Study // Athero- sclerosis. – 2011. – Vol. 216, №1. – Р. 151–156.
  16. Sh, M. S., Bobomuratov, T. A., Fayziev, N. N., Sultanova, N. S., & Dinmuxammadieva, D. R. (2022). Genetic Aspects of Juvenile Rheumatoid Arthritis. Eurasian Medical Research Periodical, 10, 1-5.MA. – 2005. – Vol. 294, №14. – Р. 1799–809.
  17. Fayziev, N. N., Mallaev, Sh. Sh., Sultanova, N. S., & Bobomuratov, T. A. Changes in the hemostasis system in children with pneumonia and optimization of their treatment. Academic Research in Educational Sciences Volume 4 | Special Issue 1 | 2023 ISSN: 2181-1385
  18. Bobomuratov T. A., Fayziev N. N., Mallaev Sh. Sh. Coronavirus infections in children, clinical features, diagnosis, treatment in children. Bulletin of the Tashkent Medical Academy No. 5 2022. S. 21-23
  19. Mallaev Sh. Sh., Fayziev N.N. Peculiarities of the clinical course of coronavirus infection in children (literature review) // JOURNAL OF HEPATO-GASTROENTEROLOGICAL RESEARCH. – 2022. – no. SI-2.
  20. Mallaev Sh.Sh, Bobomuratov T.A, Fayziev N.N., Sultanova N.S., Dinmuxammadieva D.R. Genetic Aspects of Juvenile Rheumatoid Arthritis. ISSN (E): 2795 – 7624 VOLUME 10 | JULY 2022. 1-5.
  21. Sh.Sh Mallaev, T.A Bobomuratov, N.S. Sultanova, G.A. Yusupova, A.A. Hoshimov.// Сlinical characteristics and prediction of the outcome of juvenile rheumatoid arthritis in chronotherapy// Chin J Ind Hyg Occup Dis: Vol.39 (No.7 ). pp. 135-140.
  22. Sh.Sh Mallaev, A.V Alimov Comparative efficacy of traditional therapy and chronotherapy in the treatment of juvenile rheumatoid arthritis. // New day in medicine - 2020. - T .1. No. 1 - S. 258-262.
  23. Sh.Sh. Mallaev, A.V. Alimov. Clinical course of juvenile rheumatoid arthritis and its optimization of treatment // Journal "Pediatrics" No. 2 Tashkent 2020. P. 200-203.
  24. Mallaev Sh.Sh., Alimov A.V. Clinical course of juvenile rheumatoid arthritis and its treatment optimization // Tibbiyotda yangi kun. - 2020. - No. 4 (32). - S. 68 -71. (14.00.00. - No. 22).
  25. Mallaev Sh.Sh., Alimov A.V. Clinic - laboratory manifestation of juvenile rheumatoid arthritis // Evroaziyskiy vestnik pediatrii. - 2020. - No. 3 - P. 56-60.
  26. Mallaev Sh.Sh. Modern features of the course of clinical variants of juvenile rheumatoid arthritis // Interuniversity Scientific Congress "Higher School: Scientific Research" Moscow, 2020. - P. 64 -65.
  27. Mallaev Sh.Sh. Substantiation of the chronopharmacological approach to the treatment of diffuse connective tissue diseases in children // Interuniversity Scientific Congress "Higher School: Scientific Research" Moscow, 2020. - P. 66 -67.
  28. Mallaev Sh.Sh., Alimov A.V. The functional state of the adrenal glands in children with juvenile rheumatoid arthritis // Collection of articles based on the materials of the XXXI International Scientific and Practical Conference No. 1 (28) Moscow 2020. - P. 76-80.
  29. Mallaev Sh.Sh., Alimov A.V. New approaches to the treatment of juvenile rheumatoid arthritis // Collection of articles based on the materials of the XXXI International Scientific and Practical Conference No. 2 (62) Moscow 2020. - P. 18-22.