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Abstract

This research review sheds light on an overview of serotonin and its relationship with cases of depression. The chemical activity of serotonin has been addressed, as serotonin acts as chemical messengers that act on cells throughout the human body, which starts from the calculus of early development and during puberty. In this research, we discuss how to increase serotonin through the use of drugs, which is an important field in psychiatric and biological research. We determine the normal range of serotonin in the blood through a simple blood test. The functions of serotonin, which is considered as a direct-acting neurotransmitter that is commonly stored in presynaptic vesicles. And we define the side effects and the expected results of reducing the natural ratio of serotonin in the human body

Keywords

Serotonin 5-hydroxytryptamine nervous system

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How to Cite
Yusra A. Radeef, & Zahraa Ali Abdullah. (2023). General Description of Serotonin Theory. Texas Journal of Agriculture and Biological Sciences, 15, 134–138. Retrieved from https://zienjournals.com/index.php/tjabs/article/view/3847

References

  1. Coppen, A. The biochemistry of affective disorders. Br J Psychiatry. 1967;113:1237–64.
  2. American Psychiatric Association. What Is Psychiatry? 2021. https://www. psychiatry.org/patients-families/what-is-psychiatry-menu.
  3. GlaxoSmithKline. Paxil XR. 2009. www.Paxilcr.com (site no longer available). Last accessed 27th Jan 2009.
  4. Eli Lilly. Prozac - How it works. 2006. www.prozac.com/how_prozac/ how _it _works .jsp ? req NavId=2.2. (site no longer available). Last accessed 10th Feb 2006.
  5. Healy, D. Serotonin and depression. BMJ: Br Med J. 2015;350:h1771.
  6. Pies, R. Psychiatry’s New Brain-Mind and the Legend of the “Chemical Imbalance.” 2011. https://www.psychiatrictimes.com/view/psychiatrys-new-brain-mind-andlegend-chemical-imbalance. Accessed March 2, 2021.
  7. Geddes, J.R., Andreasen, N.C., Goodwin, G.M. New Oxford Textbook of Psychiatry. Oxford, UK: Oxford University Press; 2020.
  8. Sadock, B.J., Sadock, V.A., Ruiz, P. Kaplan & Sadock’s Comprehensive Textbook of Psychiatry. 10th Editi. Lippincott Williams & Wilkins (LWW); 2017.
  9. Cowen, P.J., Browning, M. What has serotonin to do with depression? World Psychiatry. 2015;14:158–60.
  10. Harmer, C.J., Duman, R.S., Cowen, P.J. How do antidepressants work? New perspectives for refining future treatment approaches. Lancet Psychiatry. 2017;4:409–18.
  11. Yohn, C.N., Gergues, M.M., Samuels, B.A. The role of 5-HT receptors in depression. Mol Brain. 2017;10:28.
  12. Hahn, A., Haeusler, D., Kraus, C., Höflich, A.S., Kranz, G.S., Baldinger, P., et al. Attenuated serotonin transporter association between dorsal raphe and ventral striatum in major depression. Hum Brain Mapp. 2014;35:3857–66.
  13. Amid far M, Colic L, Kim MWAY-K. Biomarkers of major depression related to serotonin receptors. Curr Psychiatry Rev. 2018;14:239–44.
  14. Albert, P.R., Benkelfat, C., Descarries, L. The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Philos Trans R Soc Lond B Biol Sci. 2012;367:2378–81.
  15. Pilkington, P.D., Reavley, N.J., Jorm, A.F. The Australian public’s beliefs about the causes of depression: associated factors and changes over 16 years. J Affect Disord. 2013;150:356–62.
  16. Pescosolido, B.A., Martin, J.K., Long, J.S., Medina, T.R., Phelan, J.C., Link. B.G. A disease like any other? A decade of change in public reactions to schizophrenia, depression, and alcohol dependence. Am J Psychiatry. 2010;167:1321–30.
  17. Read, J., Renton, J., Harrop, C., Geekie, J., Dowrick, C. A survey of UK general practitioners about depression, antidepressants and withdrawal: implementing the 2019 Public Health England report. Therapeutic Advances in. Psychopharmacology. 2020;10:204512532095012.
  18. Demasi, M., Gøtzsche, P.C. Presentation of benefits and harms of antidepressants on websites: A cross-sectional study. Int J Risk Saf Med. 2020;31:53–65.
  19. Jakobsen, J.C., Gluud, C., Kirsch, I. Should antidepressants be used for major depressive disorder? BMJ Evidence-Based. Medicine. 2020;25:130–130.
  20. Moncrieff, J., Cohen, D. Do antidepressants cure or create abnormal brain states? PLoS Med. 2006;3:e240.
  21. Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., Bockting, C. Prospective biomarkers of major depressive disorder: a systematic review and met analysis. Mol Psychiatry. 2020;25:321–38.
  22. Berger, M., Gray, J.A., Roth, B.L. The expanded biology of serotonin Annual Review of Medicine.2009; 60:355–366.
  23. Gether, U., Andersen, P.H., Larsson, O. M., Schousboe, A. Neurotransmitter transporters: molecular function of important drug targets Trends in Pharmacological Sciences.2006; 27:375–383.
  24. Kristensen, A.S., Andersen, J.J., ørgensen, T.N., Sørensen, L., Eriksen, J.. Loland, C.J., Strømgaard, K., Gether, U. SLC6 neurotransmitter transporters: structure, function, and regulation Pharmacological Reviews 2011;63:585–640.
  25. Rudnick, G., Krämer, R., Blakely, R. D., Murphy, D.L., Verrey, F. (2014) The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction P flügers Archiv - European Journal of Physiology.2041;466:25–42.
  26. Navratna, V., Gouaux, E. Insights into the mechanism and pharmacology of neurotransmitter sodium symporters Current Opinion in Structural Biology.2019;54:161–170.
  27. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., Gouaux, E. (2005) Crystal structure of a bacterial homologue of na+/Cl--dependent neurotransmitter transporters Nature.2005;437:215–223.
  28. Li, D., He, L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry. 2006;12:47-54.
  29. Neumeister, A., Young, T., Stastny, J. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology (Berl) 2004;174:512-24.
  30. Anguelova, M., Benkelfat, C., Turecki, G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003;8:646-53.
  31. Anguelova, M., Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 2003;8:574-91.
  32. Gutknecht, L., Jacob, C., Strobel, A., et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dys regulation. Int J Neuropsychopharmacol 2007;10:309-20.
  33. Schoevers, R.A., Smit, F., Deeg, D.J.H., et al. Prevention of late-life depression in primary care: do we know where to begin? Am J Psychiatry 2006;163:1611-21.
  34. van 't Veer-Tazelaar, N., van Marwijk, H., van Oppen, P, et al. Prevention of anxiety and depression in the age group of 75 years and over: a randomized controlled trial testing the feasibility and effectiveness of a generic stepped care program me among elderly community residents at high risk of developing anxiety and depression versus usual care. BMC Public Health 2006;6:186.
  35. Barrett, P.M., Farrell, L.J., Ollendick, T.H., et al. Long-term outcomes of an Australian universal prevention trial of anxiety and depression symptoms in children and youth: an evaluation of the friends program. J Clin Child Adolesc Psychol. 2006;35:403-11.
  36. Schotte, C.K.W., Van Den Bossche, B., De Doncker, D., et al. A bio psychosocial model as a guide for psych education and treatment of depression. Depress Anxiety. 2006;23:312-24.
  37. Whyte, E.M., Rovner, B. Depression in late-life: shifting the paradigm from treatment to prevention. Int J Geriatr Psychiatry. 2006;21:746-51.
  38. Jorm, A.F., Griffiths, K.M. Population promotion of informal self-help strategies for early intervention against depression and anxiety. Psychol Med. 2006;36:3-6.
  39. Delamothe, T. Happiness. BMJ 2005;331:1489-90. [PMC free article]
  40. Wellbeing: an idea whose time has come. Lancet 2005;366:1412.
  41. A sensible 10-year plan for mental health. Lancet 2006;367:86.
  42. David, D.J., Gardier, A.M. The pharmacological basis of the serotonin system: Application to antidepressant response]. Encephale. 2016 Jun;42(3):255-63.
  43. Smith, C., Smith, M,, Cunningham, R., Davis, S. Recent Advances in Antiemetics: New Formulations of 5-HT3 Receptor Antagonists in Adults. Cancer Nurs. 2020 Jul/Aug;43(4):E217-E228.
  44. Kitson, S. L. 5-hydroxytryptamine (5-HT) receptor ligands. Curr Pharm Des. 2007;13(25):2621-37.
  45. Ivetic, N., Arnold, D.M., Smith, J.W., Huynh, A., Kelton, J.G., Nazy, I. A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia. Platelets. 2019;30(8):1017-1021