##plugins.themes.academic_pro.article.sidebar##

Download
pdf
Statistic
Read Counter : 118 Download : 93

##plugins.themes.academic_pro.article.main##

Abstract

Asthma cause airway obstruction and are associated with chronic airway inflammation. Interleukin -5 is mainly produced by Th2 cells, innate lymphoid cells group 2 (ILC2), mast cells, natural killer T cells (NKT), and eosinophils themselves. Material and Method: A case-control study and the implementation steps are divided into 3 main parts, include: Patient selection and sampling, examining the intensity of gene expression. Result: The present study show that the expression of IL-5 gene has increased significantly in asthma. Regarding the intensity of IL-5 gene expression in the patient and control groups, a significant difference can be observed between the two groups in terms of gene expression intensity (PValue=0.0001). Conclusion: The results of the present study show that IL-5 gene expression has been significantly changed in asthma. In terms of the intensity of IL-5 gene expression in the patient and control groups, a significant difference is observed between the two groups (P-Value=0.0001), also the experiment and analysis of the obtained ROC curve shows that a significant change in IL-5 in Asthma.

Keywords

Asthma Chronic Obstructive Pulmonary Disease COPD

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite
Baraa Jawad Kadhim, Assist. Prof. Mohammad Reza Khakzad, & Assist. Prof. Jenna Khayat Zadeh. (2023). Immunological and Molecular Evaluation of IL-5 in Asthma Patients. Texas Journal of Medical Science, 17, 39–45. https://doi.org/10.62480/tjms.2023.vol17.pp39-45
Crossref
Scopus
Google Scholar
Europe PMC

References

  1. Barnes PJ, Drazen JM. Pathophysiology of Asthma and COPD. 2002:343-59.
  2. Lambrecht BN, Hammad H. The immunology of asthma. Nature Immunology. 2015;16(1):45-56.
  3. Asher I, Haahtela T, Selroos O, Ellwood P, Ellwood E, Group GANS. Global Asthma Network survey suggests more national asthma strategies could reduce burden of asthma. Allergologia et immunopathologia. 2017;45(2):105-14.
  4. Mims JW, editor Asthma: definitions and pathophysiology. International forum of allergy & rhinology; 2015: Wiley Online Library.
  5. Maurya V, Gugnani HC, Sarma PU, Madan T, Shah A. Sensitization to Aspergillus Antigens and Occurrence of Allergic Bronchopulmonary Aspergillosis in Patients With Asthma. Chest.
  6. Greene CM, Gaughan KP. microRNAs in asthma: potential therapeutic targets. Current opinion in pulmonary medicine. 2013;19(1):66-72.
  7. Boulet L-P, Reddel HK, Bateman E, Pedersen S, FitzGerald JM, O'Byrne PM. The global initiative for asthma (GINA): 25 years later. European Respiratory Journal. 2019;54(2):1900598.
  8. Berair R, Brightling CE. Asthma therapy and its effect on airway remodelling. Drugs. 2014;74(12):1345-69.
  9. Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, et al. Airway remodelingassociated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression. Journal of Allergy and Clinical Immunology. 2003;111(6):1293- 8.
  10. Gupta S, Siddiqui S, Haldar P, Entwisle JJ, Mawby D, Wardlaw AJ, et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax. 2010;65(9):775-81.
  11. Matthaei KI, Foster PS, Young IG. The role of interleukin-5 (IL-5) in vivo: studies with IL-5 deficient mice. Memórias do Instituto Oswaldo Cruz. 1997;92:63-8.
  12. Lin H, Zhang W, Zhou T, Li W, Chen Z, Ji C, et al. Mechanism of microRNA-21 regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration. Experimental and therapeutic medicine. 2017;14(2):1441-4.
  13. Zhang Y, Xue Y, Liu Y, Song G, Lv G, Wang Y, et al. MicroRNA-146a expression inhibits the proliferation and promotes the apoptosis of bronchial smooth muscle cells in asthma by directly targeting the epidermal growth factor receptor. Experimental and Therapeutic Medicine. 2016;12(2):854-8.
  14. Gupta S, Siddiqui S, Haldar P, Raj JV, Entwisle JJ, Wardlaw AJ, et al. Qualitative analysis of high-resolution CT scans in severe asthma. Chest. 2009;136(6):1521-8.
  15. Virchow JC, Kroegel C, Walker C, Matthys H. Inflammatory determinants of asthma severity: Mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. Journal of Allergy and Clinical Immunology. 1996;98(5, Part 2):S27-S40.
  16. Aysola RS, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest. 2008;134(6):1183-91.
  17. Johansson K. ILC2s and miRNA regulation in allergy and asthma. 2018.