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Abstract
This open-label, randomized, retrospective, comparative study investigated the prognostic value of urinary NGAL (neutrophil gelatinase-associated lipocalin) levels in predicting renal allograft dysfunction in 18 patients who underwent living related donor kidney transplantation at the Samarkand Regional Multidisciplinary Medical Center between January and September 2024. Participants were followed up for three months after transplantation. Renal graft dysfunction (DGF) was defined based on the criteria of Halloran et al. Dynamic measurements of NGAL, serum creatinine, and urea during the first week of the postoperative period showed a significant decrease in these parameters in 17 of 18 patients. Graft dysfunction was observed in one case, which was accompanied by abnormalities. The data obtained confirm that NGAL is a useful biomarker for the early diagnosis and monitoring of renal graft function. This method may improve the prediction of complications and optimize the clinical management of patients after kidney transplantation.
Keywords
NGAL
kidney transplantation
graft dysfunction
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Norkuziev, Sherali Safaralievich, Kurbanov Obid Makhsudovich, Muminov Javokhir Asliddinovich, Ismatov Tuichiboy Akhrorkulovich, Norkabilov Alisher Norbekovich, Olimov Ismoilkhon Zhamolkhon ugli, & Mamatmurodov Anvar Abdusaidovich. (2025). NGAL As A Biomarker For Early Detection Of Renal Allograft Dysfunction In Living Donor Transplantation. Texas Journal of Medical Science, 43, 11–15. Retrieved from https://zienjournals.com/index.php/tjms/article/view/6092
References
- Flower DR. The lipocalin protein family: structure and function. Biochem J 1996;318(Pt 1):1-14.
- Devarajan P. Review: neutrophil gelatinase-associated lipocalin: atroponin-like biomarker for human
- acute kidney injury. Nephrology.2010;15(4):419-428.
- Bolignano D, Lacquaniti A, Coppolino G, Campo S, Arena A, Buemi M. Neutrophil gelatinaseassociated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney
- disease. Kidney Blood Press Res. 2008;31(4):255-258.
- Yigit IP, Celiker H, Dogukan A, et al. Can serum NGAL levels be used as an inflammation marker on
- hemodialysis patients with permanent catheter? Ren Fail. 2015;37(1):77-825. Schmidt-Ott KM, Mori K, Li JY, et al. Dual action of neutrophil gelatinase-associated lipocalin. J Am
- Soc Nephrol. 2007;18(2):407-413.
- Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. Accuracy of neutrophil gelatinaseassociated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review
- and meta-analysis. Am J Kidney Dis. 2009;54(6):1012-1024.
- Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J Am Soc Nephrol.
- ;22(5):810-820.
- Hall IE, Yarlagadda SG, Coca SG, et al. IL-18 and urinary NGAL predict dialysis and graft recovery
- after kidney transplantation. J Am Soc Nephrol. 2010;21(1):189-197.
- Boom H, Mallat MJ, de Fijter JW, Zwinderman AH, Paul LC. Delayed graft function influences renal
- function, but not survival. Kidney Int. 2000;58(2):859-866.
- Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine
- measurement: a report from the Laboratory Working Group of the National Kidney Disease Education
- Program. Clin Chem. 2006;52(1):5-18.
- Seo MS, Kim HJ, Kim H, Park SW. Ethyl pyruvate directly attenuates active secretion of HMGB1 in
- proximal tubular cells via induction of heme oxygenase-1. J Clin Med. 2019;8(5):629.
- Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese
- patients with chronic kidney disease. J Am Soc Nephrol. 2006;17(10):2937-2944.
- Halloran PF, Hunsicker LG. Delayed graft function: state of the art, November 10–11, 2000. Summit
- meeting, Scottsdale, Arizona, USA. Am J Transplant. 2001;1(2):115-120.
- El-Maghraby TA, Boom H, Camps JA, et al. Delayed graft function is characterized by reduced
- functional mass measured by (99m) Technetium-mercaptoacetyltriglycine renography.
- Transplantation. 2002;74(2):203-208.
- Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation.
- Lancet. 2004;364(9447):1814-1827.
- Shang W, Wang Z. The update of NGAL in acute kidney injury. Curr Protein Pept Sci.
- ;18(12):1211-1217.
- Haase-Fielitz A, Haase M, Devarajan P. Neutrophil gelatinase-associated lipocalin as a biomarker of
- acute kidney injury: a critical evaluation of current status. Ann Clin Biochem. 2014;51(Pt 3):335-351.
- Lei L, Li LP, Zeng Z, et al. Value of urinary KIM-1 and NGAL combined with serum Cys C for
- predicting acute kidney injury secondary to decompensated cirrhosis. Sci Rep. 2018;8(1):7962.
- Mitsnefes MM, Kathman TS, Mishra J, et al. Serum neutrophil gelatinase-associated lipocalin as a
- marker of renal function in children with chronic kidney disease. Pediatr Nephrol. 2007;22(1):101-
- Maas RJ, van den Brand JA, Waanders F, et al. Kidney injury molecule-1 and neutrophil gelatinaseassociated lipocalin as prognostic markers in idiopathic membranous nephropathy. Ann Clin Biochem.
- ;53(Pt 1):51-57.
- Li F, Hu L, Zhao X, et al. The value of cystatin C and urinary and serum neutrophil gelatinaseassociated lipocalin during the perioperative period of renal transplantation. Transl Androl Urol.
- ;8(5):432-441.
- Kurbonov OM, Makhmudov KO, Ismatov TA The Value of Biopsy in Histopathological Diagnosis .
- Health & Medical Sciences Volume: 2, Number 1, 2024, Page: 1-8.
- Kurbonov O.M., Makhmudov K.O., Norkuziev Sh.S., Ismatov T.A., Muminov Zh.A. Clinical review
- on living related donor kidney transplantation. International multidisciplinary journal for research &
- development. Volume 10, issue 12 (2023), P-346-351.
- Ismatov T. A. Effectiveness of Desensitizing Therapy in Kidney Transplantation in Highly Sensitized
- Patients Before Transplantation. Vol. 55 (2024): Miasto Przyszłości. P-1231-1237