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Abstract

The study included 103 patients hospitalized for SARS-CoV-2 pneumonia at the Bukhara Regional Infectious Diseases Hospital, which was reorganized into the Covid Center. Immunological studies of the blood of sick children were carried out in the laboratory of immunomorphology of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan. The indicators of interferon (INF-a, IFN-γ), cytokines (IL4, IL18) and biochemical tests in the blood were studied. In patients with SARS-CoV-2 pneumonia and type 2 diabetes, total bilirubin has a high relationship with the diabetogenic cytokine IL-18 - r = 0.42, against the background of a noticeable negative relationship with IL-4 (r = -0.30) and INF γ -r=-0.34. At the same time, the free fraction of bilirubin, like total bilirubin, has noticeable negative connections with IL-4 (r = -0.22) and IFN-γ r = -0.34, and has a significant positive connection with IL-18 - r = 0.34

Keywords

SARS CoV-2 pneumonia

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How to Cite
Aslonova Marjona Ramazonova. (2023). Correlation Relationship of Interferons, Cytokines with Biochemical Mediators of Inflammation in The Blood in The Association of Covid-19 and Type 2 Diabetes. Texas Journal of Medical Science, 26, 70–77. https://doi.org/10.62480/tjms.2023.vol26.pp70-77

References

  1. Allard R, Leslers P, Tremblay C, Tannenbaum TN. Diabetes and the North of Pandemic Influenza A (H1H1) infection. Diabetes Sarah. 2010;33(7):1491–1493.
  2. Chen Zh, Wu C, Wang H, Yu Zh, Sun Z. Thе impact of COVID-19 on blood gluсose: а systematic review and meta-analysis. Front Endosrinol (Lausanne). 2020;11:574541.
  3. Guo W, Li M, Dong Y, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020;36(7):e3319. 10.1002/dmrr.3319
  4. Gupta R, Ghosh A, Singh AK, Misra A. Clinical considerations for patients with diabetes in times of COVID-19 epidemic. Diabetes Metab Syndr. 2020;14(3):211–212.
  5. Lee YH, Kim SR, Han DҲ, et al. Senescent T Cells predisposed the development of hyperglycemia in humans. Diabetes. 2019;68(1):156–162.
  6. Muniyappa R, Gubbi S. COVID-19 pandemic, coronavirus, and diabetes mellitus. Am J Physiol Endosrinol Metab (2020) 318(5):E736–E41. 10.1152/azhpendo.00124.2020
  7. Nyambuya TM, Dludla PV, Mhinwa V, Nkambule BB.T-cell activation and cardiovascular risk in adults with type 2 diabetes mellitus: a systematic review and meta-analysis.Clin Immunol. 2020;210:108313.
  8. Облокулов, А. Р., & Ниёзов, Г. Е. (2020). Cлиниcал анд епидемиологиcал чараcтеристиcс оф патиентс wитҳ CОВИД-19. Интернатионал Жоурнал оф Пҳармаcеутиcал Ресеарч, 3749-3752.
  9. Mukhammadieva M.I. (2022). Modern Clinical and Biochemical Characteristics of Liver Cirrhosis Patients of Viral Etiology with Spontaneous Bacterial Peritonitis //Texas Journal of Medical Science. – 2022.- P. 86-90.
  10. Облоқулов, А. Р., Ниёзов, Г. Е., Елмуродова, А. А., & Орифов, Д. У. (2020). Cлиниcал чараcтеристиcс оф патиентс wитҳ CОВИД-19.Интердисcиплинарй Аппроачес то Медиcине,1(2), 40-43.
  11. World Health Organization Coronavirus Disease 2019 (COVID-19) situation report – 92.
  12. Ильин В.П. Корреляционный анализ количественных данных в медико-биологических исследованиях// Бюллетень ВСНЦ СО РАМН- 2013,-№4(92)-с.125-130]
  13. Аслонова М.Р., (2023). Оценка интерферонового статуса у пациентов с сахарным диабетом 2 типа, инфицированных covid-19 // Журнал гуманитарных и естественных наук. – 2023. № 3 (09). С. 196-202.
  14. Облокулов, А. Р., Ниезов, Г. Э., & Ражабов, А. Р. (2021). Cовид-Ассоциированная Коагулопатия У Пациентов Новой Коронавирусной Инфекции. Cентрал асиан жоурнал оф медиcал анд натурал сcиенcес, 124-130.
  15. Mukhtorova Shokhida Abdulloevna. (2023). Microbiological Indicators of Patients Infected with SarsCov-2. Texas Journal of Medical Science, 21, 41–45.Retrieved from https://www.zienjournals.com/index.php/tjms/article/view/4116
  16. Mухаммадиевa M.И. (2023). Bирус этиологияли жигар циррози беморларида спонтан бактериал перитонит билан асоратланишнинг профилактикаси ва давосини такомиллаштириш//Oriental Renaissance: Innovative, educational, natural and social sciences. -2023.-P.947-953.
  17. Облоқулов А.Р., Холов Ў.А., Жалилова А.С. CОВИД-19 инфекцияси тасдиқланган беморларнинг микробиологик параметрлари. // Новый День в Медицине. 2022 -2 (40) 363-369 б.
  18. Облоқулов, А., & Муҳаммадиева, М. (2022). КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА СПОНТАННОГО БАКТЕРИАЛЬНОГО ПЕРИТОНИТА ПРИ ЦИРРОЗЕ ПЕЧЕНИ ВИРУСНОЙ ЭТИОЛОГИИИ. Журнал вестник врача, 1(3), 66–69. извлечено от https://inlibrary.uz/index.php/doctors_herald/article/view/2016
  19. Oblokulov. A.R., M.I. Mukhammadieva.(2022). Clinical and biochemical characteristics of liver cirrhosis patients of viral etiology with spontaneous bacterial peritonitis//ACADEMICIA GLOBE: INDERSCIENSE RESEARCH.-2022.- P. 210-216