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Abstract

Avascular necrosis of bones (osteonecrosis) has developed as a bad consequence of the COVID-19 (SARS-CoV-2) pandemic that has swept the world. In 5-58% of patients with the type of covid19 fertilizer, the bones were affected by avascular necrosis. In 39% of patients with SARS-CoV-2, avascular necrosis of the hip bone developed within a few months after atypical pneumonia. Avascular necrosis is a disease that often develops in people of working age (average age is 33-45 years) and leads to severe disability associated with the death of bone tissue in a particular area. Discussions about the pathogenesis of postcovid avascular necrosis, the possibility of its diagnosis and treatment in the early stages are subject to active discussion. Given that COVID-19 infection is common among young people and working-age people, early diagnosis and treatment of this form of osteonecrosis is of great social and economic importance

Keywords

avascular necrosis of the femoral head etiology COVID-19 glucocorticoids

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How to Cite
M.Yu. Karimov, & J.Sh. Kayumov. (2023). Complex-Conservative Treatment of Sars-Cov-2 Associated Early-Stage Avascular Necrosis of The Femoral Head. Texas Journal of Medical Science, 26, 43–52. https://doi.org/10.62480/tjms.2023.vol26.pp43-52

References

  1. WHO coronavirus disease (COVID-19) Dashboard. Available from:
  2. https://covid19.who.int/table
  3. Leung T.Y.M., Chan A.Y.L., Chan E.W., Chan V.K.Y., Chui C.S.L., Cowling B.J. et al. Short- and potential longterm adverse health outcomes of COVID-19: a rapid review. Emerg Microbes Infect. 2020; 9 (1) : 2190-2199. doi:10.1080/ 22221751.2020.1825914.
  4. Mahase E. Covid-19: What do we know about «Long COVID» BMJ. 2020;370:m2815. doi: 10.1136/bmj.m2815.
  5. Agarwala S.R., Vijayvargiya M., Pandey P. Avascular necrosis as a part of ‘long COVID-19’. BMJ Case Rep. 2021;14(7): e242101. doi: 10.1136/bcr-2021-242101.
  6. Griffith J.F. Musculoskeletal complications of severe acute respiratory syndrome. Semin Musculoskelet Radiol. 2011;15(5):554-560. doi: 10.1055/s-0031-1293500.
  7. Hong N., Du X.K. Avascular necrosis of bone in severe acute respiratory syndrome. Clin Radiol. 2004; 59 (7):602-608. doi: 10.1016/j.crad.2003.12.008.
  8. Lv H., de Vlas S.J., Liu W., Wang T.B., Cao Z.Y., Li C.P. et al. Avascular osteonecrosis after treatment of SARS: a 3-year longitudinal study. Trop Med Int Health. 2009;14 Suppl 1(Suppl 1):79-84. doi: 10.1111/j.1365-3156.2008.02187.x.
  9. Bashkova I.B., Madyanov I.V., Mikhailov A.S. Osteonecrosis of the femoral head induced by a new coronavirus infection. RMJ. 2022;6:71-74.
  10. Sardu C., Gambardella J., Morelli M.B., Wang X., Marfella R., Santulli G. Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease A Comprehensive Evaluation of Clinical and Basic Evidence. J Clin Med. 2020;9(5):1417. doi: 10.3390/jcm9051417.
  11. Escher R., Breakey N., Lammle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020;190:62. doi: 10.1016/j.thromres. 2020.04.014.
  12. Gralinski L.E., Ferris M.T., Aylor D.L., Whitmore A.C., Green R., Frieman M.B. et al. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet. 2015;11(10): e1005504. doi: 10.1371/journal.pgen.1005504.
  13. Oxley T.J., Mocco J., Majidi S., Kellner C.P., Shoirah H., Singh I.P. et al. Large-Vessel Stroke as a Presenting Feature of COVID-19 in the Young. 2020;382(20): e60. doi: 10.1056/NEJMc2009787.
  14. Channappanavar R., Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529-539. doi: 10.1007/s00281-017-0629-x.
  15. Van Reeth K., Van Gucht S., Pensaert M. Correlations between lung proinflammatory cytokine levels, virus replication, and disease after swine influenza virus challenge of vaccination-immune pigs. Viral Immunol. 2002;15(4):583-594. doi: 10.1089/088282402320914520.
  16. Nie S., Han S., Ouyang H., Zhang Z. Coronavirus Disease 2019-related dyspnea cases difficult to interpret using chest computed tomography. Respir Med. 2020;167:105951. doi: 10.1016/j.rmed.2020.105951.
  17. Polyakova Yu.V., Papichev E.V., Akhverdyan Yu.R., Sivordova L.E., Zavodovsky B.V. New coronavirus infection – direct and indirect effect on patients with diseases of the musculoskeletal system and connective tissue. Modern problems of science and education. 2021;(6). Access mode: https://science-education.ru/ru/article /view?id=31342.
  18. Mushtin N.E., Ed A.N., Dulaev A.K., Ilyushenko K.G., Shmelev A.V. The influence of the new coronavirus infection COVID-19 on the development of osteonecrosis. In: Medical care for injuries, new in organization and technology, the role of the national public professional organization of traumatologists in the healthcare system of the Russian Federation. Saint-Petersburg; 2021. c. 98-99.
  19. Strehl C., Ehlers L., Gaber T., Buttgereit F. Glucocorticoids-All-Rounders Tackling the Versatile Players of the Immune System. Front Immunol. 2019;10:1744. doi: 10.3389/fimmu.2019.01744.
  20. Russell B., Moss C., Rigg A., Van Hemelrijck M. COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? Ecancermedicalscience. 2020;14:1023. doi: 10.3332/ecancer.2020.1023.
  21. Russell B., Moss C., George G., Santaolalla A., Cope A., Papa S. et al. Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence. Ecancermedicalscience. 2020;14:1022. doi: 10.3332/ecancer.2020.1022.
  22. Arabi Y.M., Fowler R., Hayden F.G. Critical care management of adults with community-acquired severe respiratory viral infection. Intensive Care Med. 2020;46(2):315-328. doi: 10.1007/s00134-020-05943-5.
  23. Lau E.M., Chan F.W., Hui D.S., Wu A.K., Leung P.C. Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong. Bone. 2005;37(3):420-424. doi: 10.1016/j.bone.2005.04.018.
  24. Yang X., Yu Y., Xu J., Shu H., Xia J. Liu H. et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5.
  25. Villar J., Ferrando C., Martнnez D., Ambrуs A., Muсoz T., Soler J.A. et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respir Med. 2020;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5.
  26. RECOVERY Collaborative Group, Horby P., Lim W.Sh., Emberson J.R., Mafham M., Bell J.L. et al. Dexamethasone in Hospitalized Patients with COVID-19 —Preliminary Report. NEnglJMed. 2021; 384(8):693-704. doi: 10.1056/NEJMoa2021436.
  27. Powell C., Chang C., Naguwa S.M., Cheema G., Gershwin M.E. Steroid induced osteonecrosis: An analysis of steroid dosing risk. Autoimmun Rev. 2010;9(11):721-743. doi: 10.1016/j.autrev.2010.06.007.
  28. Koromila T., Baniwal S.K., Song Y.S., Martin A., Xiong J., Frenkel B. Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells. J Cell Biochem. 2014;115(1):27-33. doi: 10.1002/jcb.24646.
  29. Matthews B. Involvement of the osteoblast in Paget’s disease of bone. Medicine. 2009. Available from: https://www.semanticscholar.org/paper/Involvement-of-the-osteoblast-in-Paget%27s-disease-of-Matthews/c20b73cf3d1e1d6ed15801a3ac5e230459fcf1b7.
  30. O’Brien C.A., Jia D., Plotkin L.I., Bellido T., Powers C.C., Stewart S.A. et al. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 2004;145(4):1835-1841. doi: 10.1210/en.2003-0990.
  31. Koo K.H., Kim R., Kim Y.S., Ahn I.O., Cho S.H., Song H.R. et al. Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol. 2002;21(4):299-303. doi: 10.1007/s100670200078.
  32. Kerachian M.A., Sйguin C., Harvey E.J. Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol. 2009;114(3-5):121-128. doi: 10.1016/j.jsbmb.2009.02.007.
  33. Xu Y., Chen Y., Tang X. Guidelines for the diagnosis and treatment of coronavirus disease 2019 (COVID-19) in China. Glob Health Med. 2020;2(2):66-72. doi: 10.35772/ghm.2020.01015.
  34. Zheng Y., Xiong C., Liu Y., Qian X., Tang Y., Liu L. et al. Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020. Pharmacol Res. 2020;157:104821. doi: 10.1016/j.phrs.2020.104821.
  35. Zhao R., Wang H., Wang X., Feng F. Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis. Osteoporos Int. 2017;28(3):1027-1034. doi: 10.1007/s00198-016-3824-z.
  36. Shen J., Liang B.L., Zeng Q.S., Chen J.Y., Liu Q.Y., Chen R.C. et al. [Report on the investigation of lower extremity osteonecrosis with magnetic resonance imaging in recovered severe acute respiratory syndrome in Guangzhou]. Zhonghua Yi Xue Za Zhi. 2004;84(21):1814-1817. (In Chinese).
  37. Motomura G., Yamamoto T., Irisa T., Miyanishi K., Nishida K., Iwamoto Y. Dose effects of corticosteroids on the development of osteonecrosis in rabbits. J Rheumatol. 2008;35(12):2395-2399. doi: 10.3899/jrheum.080324.
  38. Marsh J.C., Zomas A., Hows J.M., Chapple M., Gordon-Smith E.C. Avascular necrosis after treatment of aplastic anaemia with antilymphocyte globulin and high-dose methylprednisolone. Br J Haematol. 1993;84(4):731-735. doi: 10.1111/j.1365-2141.1993.tb03153.x.
  39. Mont M.A., Pivec R., Banerjee S., Issa K., Elmallah R.K., Jones L.C. High-Dose Corticosteroid Use and Risk of Hip Osteonecrosis: Meta-Analysis and Systematic Literature Review. J Arthroplasty. 2015;30(9):1506-1512.e5. doi: 10.1016/j.arth.2015.03.036.
  40. Guo K.J., Zhao F.C., Guo Y., Li F.L., Zhu L., Zheng W. The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: a retrospective study. Bone Joint J. 2014;96-B(2):259-262. doi: 10.1302/0301-620X.96B2.31935.
  41. Rademaker J., Dobro J.S., Solomon G. Osteonecrosis and human immunodeficiency virus infection. J Rheumatol. 1997;24(3):601-604.
  42. Chan M.H., Chan P.K., Griffith J.F., Chan I.H., Lit L.C., Wong C.K. et al. Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy. Pathology. 2006;38(3):229-235. doi: 10.1080/00313020600696231.
  43. Richards R.N. Short-term Corticosteroids and Avascular Necrosis: Medical and Legal Realities. Cutis. 2007;80(4):343-348.
  44. Zhao F.C., Li Z.R., Guo K.J. Clinical analysis of osteonecrosis of the femoral head induced by steroids. Orthop Surg. 2012;4(1):28-34. doi: 10.1111/j.1757-7861.2011.00163.x.
  45. Zhao F.C., Hu H.X., Zheng X., Cang D.W., Liu X., Zhang J.Z. et al. Clinical analysis of 23 cases of steroid-associated osteonecrosis of the femoral head with normal initial magnetic resonance imaging presentation. Medicine (Baltimore). 2017;96(49): e8834. doi: 10.1097/MD.0000000000008834.
  46. Sun W., Li Z., Shi Z., Wang B., Gao F., Yang Y. et al. Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms. Eur J Orthop Surg Traumatol. 2014;24(4):525-529. doi: 10.1007/s00590-013-1223-0.
  47. Wei B., Wei W. Identification of aberrantly expressed of serum microRNAs in patients with hormoneinduced non-traumatic osteonecrosis of the femoral head. Biomed Pharmacother. 2015;75:191-195. doi: 10.1016/j.biopha.2015.07.016.
  48. Hsu S.L., Wang C.J., Lee M.S., Chan Y.S., Huang C.C., Yang K.D. Cocktail therapy for femoral head necrosis of the hip. Arch Orthop Trauma Surg. 2010;130(1):23-29. doi: 10.1007/s00402-009-0918-5.
  49. Wong T., Wang C.J., Hsu S.L., Chou W.Y., Lin P.C., Huang C.C. Cocktail therapy for hip necrosis in SARS patients. Chang Gung Med J. 2008;31(6):546-553.
  50. Wang W., Zhang N., Guo W., Gao F. Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteen year follow-up. Int Orthop. 2018;42(7):1551-1556. doi: 10.1007/s00264-018-3907-x.
  51. Klumpp R., Trevisan C. Aseptic osteonecrosis of the hip in the adult: current evidence on conservative treatment. Clin Cases Miner Bone Metab. 2015;12(Suppl1):39-42. doi: 10.11138/ccmbm/2015.12.3s.039.
  52. Agarwala S., Banavali S.D., Vijayvargiya M. Bisphosphonate Combination Therapy in the Management of Postchemotherapy Avascular Necrosis of the Femoral Head in Adolescents and Young Adults: A Retrospective Study From India. J Glob Oncol. 2018;4: 1-11. doi: 10.1200/JGO.17.00083.
  53. Ramachandran M., Ward K., Brown R.R., Munns C.F., Cowell C.T., Little D.G. Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. J Bone Joint Surg Am. 2007;89(8):1727-1734. doi: 10.2106/JBJS.F.00964.
  54. Karim A.R., Cherian J.J., Jauregui J.J., Pierce T., Mont M.A. Osteonecrosis of the knee: review. Ann Transl Med. 2015;3(1):6. doi: 10.3978/j.issn.2305-5839.2014.11.13.
  55. Zywiel M.G., McGrath M.S., Seyler T.M., Marker D.R., Bonutti P.M., Mont M.A. Osteonecrosis of the knee: a review of three disorders. Orthop Clin North Am. 2009;40(2):193-211. doi: 10.1016/j.ocl.2008.10.010.
  56. Hong Y.C., Luo R.B., Lin T., Zhong H.M., Shi J.B. Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis. Biomed Res Int. 2014;2014:716538. doi: 10.1155/2014/716538.
  57. Cross M., Macara M., Little E., Chan M., Little D., Buchbinder R. et al. Efficacy of zoledronate in treating osteonecrosis of femoral head: a randomized controlled trial Abstracts. Osteoarthritis and Cartilage. 2018;26(Suppl 1):S309-S310. doi: 10.1016/j.joca.2018.02.622.
  58. Agarwala S., Vijayvargiya M. Single Dose Therapy of Zoledronic Acid for the Treatment of Transient Osteoporosis of Hip. Ann Rehabil Med. 2019;43(3):314-320. doi: 10.5535/arm.2019.43.3.314.
  59. Rolvien T., Schmidt T., Butscheidt S., Amling M., Barvencik F. Denosumab is effective in the treatment of bone marrow oedema syndrome. Injury. 2017;48(4):874-879. doi: 10.1016/j.injury.2017.02.020.
  60. Родионова С.С., Еловой-Вронский А.А., Бернакевич А.И. Альфакальцидол или колекальциферол в комбинации с ибандроновой кислотой при лечении постменопаузального системного остеопороза. Остеопороз и остеопатии. 2014;17(1):21-24. Rodionova S.S., Elovoy-Vronskiy A.A., Bernakevich A.I. [Alfacalcidol or cholecalciferol in combination with ibandronic acid in the treatment of postmenopausal systemic osteoporosis]. Osteoporoz and osteopatii [Osteoporosis and Bone Diseases]. 2014;17(1):21-24. (In Russian).
  61. Grant W.B., Lahore H., McDonnell S.L., Baggerly C.A., French C.B., Aliano J.L. et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. doi: 10.3390/nu12040988.
  62. Annweiler C., Hanotte B., Grandin de l’Eprevier C., Sabatier J.M., Lafaie L., Cйlarier T. Vitamin D and survival in COVID-19 patients: A quasi-experimental study. J Steroid Biochem Mol Biol. 2020;204:105771. doi: 10.1016/j.jsbmb.2020.105771.
  63. Kakodkar P., Kaka N., Baig M.N. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus. 2020;12(4):e7560. doi: 10.7759/cureus.7560.
  64. Gangji V., Soyfoo M.S., Heuschling A., Afzali V., Moreno-Reyes R., Rasschaert J. et al. Non traumatic osteonecrosis of the femoral head is associated with low bone mass. Bone. 2018;107:88-92. doi: 10.1016/j.bone.2017.11.005.
  65. Белая Ж.Е., Белова К.Ю., Бирюкова Е.В., Дедов И.И., Дзеранова Л.К., Драпкина О.М. и др. Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза. Остеопороз и остеопатии. 2021;24(2):4-47. doi: 10.14341/osteo12930.
  66. Torgashin A.N., Rodionova S.S., Shumsky A.A., Makarov M.A., Torgashina A.V., Akhtyamov I.F. et al. [Treatment of aseptic necrosis of the femoral head. Clinical guidelines]. Nauchno-prakticheskaya revmatologiya [Rheumatology Science and Practice]. 2020;58(6):637-645. (In Russian).
  67. Jger M., Zilkens C., Bittersohl B., Matheney T., Kozina G., Blondin D. et al. Efficiency of iloprost treatment for osseous malperfusion. Int Orthop. 2011;35(5):761-765. doi: 10.1007/s00264-010-0998-4.
  68. Becker A., Landgraeber S., Haversath M., Li X., Zilkens C. et al. Long-term Clinical Results after Iloprost Treatment for Bone Marrow Edema and Avascular Necrosis. Orthop Rev (Pavia). 2016;8(1):6150. doi: 10.4081/or.2016.6150.
  69. Glueck C.J., Freiberg R.A., Sieve L., Wang P. Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin Orthop Relat Res. 2005;(435):164-170. doi: 10.1097/01.blo.0000157539.67567.03.
  70. Billett H.H., Reyes-Gil M., Szymanski J., Ikemura K., Stahl L.R., Lo Y. et al. Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on Mortality. Thromb Haemost. 2020;120(12):1691-1699. doi: 10.1055/s-0040-1720978.
  71. Ramachandran M., Ward K., Brown R.R., Munns C.F., Cowell C.T., Little D.G. Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. J Bone Joint Surg Am. 2007;89(8):1727-1734. doi: 10.2106/JBJS.F.00964.
  72. Karim A.R., Cherian J.J., Jauregui J.J., Pierce T., Mont M.A. Osteonecrosis of the knee: review. Ann Transl Med. 2015;3(1):6. doi: 10.3978/j.issn.2305-5839.2014.11.13.
  73. Zywiel M.G., McGrath M.S., Seyler T.M., Marker D.R., Bonutti P.M., Mont M.A. Osteonecrosis of the knee: a review of three disorders. Orthop Clin North Am. 2009;40(2):193-211. doi: 10.1016/j.ocl.2008.10.010.
  74. Hong Y.C., Luo R.B., Lin T., Zhong H.M., Shi J.B. Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis. Biomed Res Int. 2014;2014:716538. doi: 10.1155/2014/716538.
  75. Trancik T., Lunceford E., Strum D. The effect of electrical stimulation on osteonecrosis of the femoral head. Clin Orthop Relat Res. 1990;(256):120-124.
  76. Rajagopal M., Balch Samora J., Ellis T.J. Efficacy of core decompression as treatment for osteonecrosis of the hip: a systematic review. Hip Int. 2012;22(5):489-493. doi: 10.5301/HIP.2012.9748.