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Abstract

In 98 patients, an analysis of the genetic risk factor for the development of chronic venous insufficiency was carried out by studying the frequency of distribution of alleles and genotypes of the C936T polymorphism in the VEGFA gene. In both groups, the actual distribution of C807T polymorphism genotypes corresponded to those expected under the Hardy-Weinberg equilibrium (p


<0.05). A significant relationship was established between the risk of developing chronic venous insufficiency and the distribution of predisposing/protective variants of the C807T polymorphism genotypes in the VEGFA gene. These data allow us to suggest testing this locus to predict the risk of occurrence and progression of chronic venous insufficiency>

Keywords

chronic venous insufficiency vascular endothelial growth factor genetic polymorphism

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How to Cite
Vasilevskiy Eduard Aleksandrovich. (2023). The Role of the Vegfa C936t Polymorphism in the Development of Chronic Venous Insufficiency of the Legs And Its Analysis. Texas Journal of Medical Science, 25, 28–31. https://doi.org/10.62480/tjms.2023.vol25.pp28-31

References

  1. Davies, A.H. The Seriousness of Chronic Venous Disease: A Review of Real-World Evidence. Adv. Ther. 2019, 36, 5–12.
  2. Iaresko M., Kolesnikova E. The role of polymor-phism - 634 G/C (rs2010963) of VEGF-A gene in the development of hypertension and obesity in premenopausal women // Georgian. Med. News. – 2016. – Vol. 256-257. – Р. 33-37.
  3. Kowalewski R., Sobolewski K., Wolanska M., Gacko M. Matrix metalloproteinases in the vein wall // Int. Angiol. – 2004. – Vol. 23, №2. – Р. 164-169.
  4. Ligi, D.; Croce, L.; Mannello, F. Chronic venous disorders: The dangerous, the good, and the diverse. Int. J. Mol. Sci. 2018, 19, 2544.
  5. Melincovici C.S., Boşca A.B., Şuşman S. et al. Vascular endothelial growth factor (VEGF) – key factor in normal and pathological angiogenesis // Rom. J. Morphol. Embryol. – 2018. – Vol. 59, №2. – Р. 455-467.
  6. Müller-Bühl U., Leutgeb R., Engeser P. et al. Varicose veins are a risk factor for deep venous thrombo-sis in general practice patients // Vasa. – 2012. – Vol. 41, №5. – Р. 360-365.
  7. Nicolaides, A.N.; Labropoulos, N. Burden and Suffering in Chronic Venous Disease. Adv. Ther. 2019, 36
  8. Posch F., Thaler J., Zlabinger G.J. et al. Soluble Vas-cular Endothelial Growth Factor (sVEGF) and the Risk of Venous Thromboembolism in Patients with Cancer: Results from the Vienna Cancer and Thrombosis Study (CATS) // Clin. Cancer Res. – 2016. – Vol. 22, №1. – Р. 200-206.
  9. Shibuya M. Vascular endothelial growth factor and its receptor system: physiological functions in angio-genesis and pathological roles in various diseases // J. Biochem. – 2013. – Vol. 153, №1. – Р. 13-9.
  10. Vasilevskiy E.A., Aleinik V.A. Musashaihov H.T., Dadabaev O.T. Interrelation of endothelial dysfunction gene polymorphism with the risk of developing chronic venous insufficiency of the veins of the lower extremities //JournalNX- A Multidisciplinary Peer Reviewed Journal. –2022. – №11(8). –P. 273-278.
  11. Wang Y., Zheng G., Meng X., Wang B. The effects of VEGF on deep venous thrombosis in the periop-erative period of elderly fracture patients // Pak. J. Pharm. Sci. – 2018. – Vol. 31, №6 (Special). – Р. 2799-2803.