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Abstract

Uric acid is the final product of purine metabolism and is synthesized mainly in the liver and intestine, from xanthine, by the action of xanthine oxidoreductase. The serum uric acid concentration is the result of equilibrium among various factors: dietary intake, endogenous synthesis, and renal excretion.

Keywords

Uric acid T2DM Serum Ca

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How to Cite
Dr. KHAMIS Y. C. AL-QUBAEISSY, Dr. Muntaha Hamad Shlaka, & Dr. Iman Jubair Mousa. (2023). Association between serum uric acid level and bone mineral density in postmenopausal Iraqi women. Texas Journal of Medical Science, 19, 131–138. https://doi.org/10.62480/tjms.2023.vol19.pp131-138
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References

  1. Ahn S.H., Lee S.H., Kim B.J., Lim K.H., Bae S.J., Kim E.H., Kim H.K., Choe J.W., Koh J.M., Kim G.S. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporos. Int. 2013;24:2961–2970. doi 10.1007/s00198-013-2377-7. [PubMed] [CrossRef] [Google Scholar]
  2. Lee Y.J., Hong J.Y., Kim S.C., Joo J.K., Na Y.J., Lee K.S. The association between oxidative stress and bone mineral density according to the menopausal status of Korean women. Obs. Gynecol. Sci. 2015;58:46–52. doi: 10.5468/ogs.2015.58.1.46. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  3. Hershfield M.S., Roberts L.J., 2nd, Ganson N.J., Kelly S.J., Santisteban I., Scarlett E., Jaggers D., Sundy J.S. Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proc. Natl. Acad. Sci. USA. 2010;107:14351–14356. doi: 10.1073/pnas.1001072107. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  4. Lane N.E. Epidemiology, etiology, and diagnosis of osteoporosis. Am. J. Obstet. Gynecol. 2006;194:S3–S11. doi: 10.1016/j.ajog.2005.08.047. [PubMed] [CrossRef] [Google Scholar]
  5. Lean J.M., Davies J.T., Fuller K., Jagger C.J., Kirstein B., Partington G.A., Urry Z.L., Chambers T.J. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J. Clin. Investig. 2003;112:915–923. doi: 10.1172/JCI200318859. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  6. Cutler R.G., Camandola S., Malott K.F., Edelhauser M.A., Mattson M.P. The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Curr. Top. Med. Chem. 2015;15:2233–2238. doi: 10.2174/1568026615666150610143234. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  7. Rasheed A., Khurshid R., Aftab L. Bone mass measurement and factors associated with risk of fracture in a group of peris- and postmenoupausal women. J. Ayub Med. Coll. Abbottabad Jamc. 2008;20:48–51. [PubMed] [Google Scholar]
  8. Hediger M.A., Johnson R.J., Miyazaki H., Endou H. Molecular physiology of urate transport. PhysIOL. 2005;20:125–133. doi 10.1152/physiol.00039.2004. [PubMed] [CrossRef] [Google Scholar]
  9. Makovey J., Macara M., Chen J.S., Hayward C.S., March L., Seibel M.J., Sambrook P.N. Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: A longitudinal study. Bone. 2013;52:400–406. doi 10.1016/j.bone.2012.10.025. [PubMed] [CrossRef] [Google Scholar]
  10. Lin X., Zhao C., Qin A., Hong D., Liu W., Huang K., Mo J., Yu H., Wu S., Fan S. Association between serum uric acid and bone health in general population: A large and multicentre study. Oncotarget. 2015;6:35395–35403. doi: 10.18632/oncotarget.6173. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  11. Xiong A., Yao Q., He J., Fu W., Yu J., Zhang Z. No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity-a Mendelian randomization study. Osteoporos. Int. 2016;27:1031–1039. doi 10.1007/s00198-015-3341-5. [PubMed] [CrossRef] [Google Scholar]
  12. Zhang D., Bobulescu I.A., Maalouf N.M., Adams-Huet B., Poindexter J., Park S., Wei F., Chen C., Moe O.W., Sakhaee K. Relationship between serum uric acid and bone mineral density in the general population and in rats with experimental hyperuricemia. J. Bone Min. Res. 2015;30:992–999. doi: 10.1002/jbmr.2430. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  13. Wang L., Hu W., Wang J., Qian W., Xiao H. Low serum uric acid levels in patients with multiple sclerosis and neuromyelitis optica: An updated meta-analysis. Mult. Scler. Relat. Disord. 2016;9:17–22. doi: 10.1016/j.msard.2016.05.008. [PubMed] [CrossRef] [Google Scholar]
  14. Paul B.J., Anoopkumar K., Krishnan V. Asymptomatic hyperuricemia: Is it time to intervene? Clin. Rheumatol. 2017;36:2637–2644. doi: 10.1007/s10067-017-3851-y. [PubMed] [CrossRef] [Google Scholar]
  15. Borghi C., Verardi F.M., Pareo I., Bentivenga C., Cicero A.F. Hyperuricemia and cardiovascular disease risk. Expert Rev. Cardiovasc. Ther. 2014;12:1219–1225. doi 10.1586/14779072.2014.957675. [PubMed] [CrossRef] [Google Scholar]
  16. Cappuccio F.P., Strazzullo P., Farinaro E., Trevisan M. Uric acid metabolism and tubular sodium handling. Results from a population-based study. JAMA. 1993;270:354–359. doi: 10.1001/jama.1993.03510030078038. [PubMed] [CrossRef] [Google Scholar]
  17. de Oliveira E.P., Burini R.C. High plasma uric acid concentration: Causes and consequences. Diabetol. Metab. Syndr. 2012;4:12. Doi 10.1186/1758-5996-4-12. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  18. Dehghan A., van Hoek M., Sijbrands E.J., Hofman A., Witteman J.C. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008;31:361–362. doi 10.2337/dc07-1276. [PubMed] [CrossRef] [Google Scholar]
  19. Wang J.Y., Chen Y.L., Hsu C.H., Tang S.H., Wu C.Z., Pei D. Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents. J. Pediatrics. 2012;161:753–756.e752. doi 10.1016/j.jpeds.2012.03.036. [PubMed] [CrossRef] [Google Scholar]
  20. Edwards N.L. The role of hyperuricemia and gout in kidney and cardiovascular disease. Clevel. Clin. J. Med. 2008;75 ((Suppl. S5)):S13–S16. doi 10.3949/ccjm.75.Suppl_5.S13. [PubMed] [CrossRef] [Google Scholar]
  21. Kim Y., Kang J., Kim G.T. Prevalence of hyperuricemia and its associated factors in the general Korean population: An analysis of a population-based nationally representative sample. Clin. Rheumatol. 2018;37:2529–2538. Doi 10.1007/s10067-018-4130-2. [PubMed] [CrossRef] [Google Scholar]
  22. Luk A.J., Simkin P.A. Epidemiology of hyperuricemia and gout. Am. J. Manag. Care. 2005;11:S435–S442. [PubMed] [Google Scholar]
  23. Masseoud D., Rott K., Liu-Bryan R., Agudelo C. Overview of hyperuricaemia and gout. Curr. Pharm. Des. 2005;11:4117–4124. doi: 10.2174/138161205774913318. [PubMed] [CrossRef] [Google Scholar]
  24. Dalbeth N., Merriman T. Crystal ball gazing: New therapeutic targets for hyperuricaemia and gout. Rheumatology. 2009;48:222–226. doi 10.1093/rheumatology/ken460. [PubMed] [CrossRef] [Google Scholar]
  25. Glantzounis G.K., Tsimoyiannis E.C., Kappas A.M., Galaris D.A. Uric acid and oxidative stress. Curr. Pharm. Des. 2005;11:4145–4151. doi: 10.2174/138161205774913255. [PubMed] [CrossRef] [Google Scholar]
  26. Lippi G., Montagnana M., Franchini M., Favaloro E.J., Targher G. The paradoxical relationship between serum uric acid and cardiovascular disease. Clin. Chim. Acta Int. J. Clin. Chem. 2008;392:1–7. doi: 10.1016/j.cca.2008.02.024. [PubMed] [CrossRef] [Google Scholar]
  27. Sahni S., Hannan M.T., Blumberg J., Cupples L.A., Kiel D.P., Tucker K.L. Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: The Framingham Osteoporosis Study. Am. J. Clin. Nutr. 2009;89:416–424. doi: 10.3945/ajcn.2008.26388. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  28. Sanchez-Rodriguez M.A., Ruiz-Ramos M., Correa-Munoz E., Mendoza-Nunez V.M. Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet. Disord. 2007;8:124. doi 10.1186/1471-2474-8-124. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  29. Sugiura M., Nakamura M., Ogawa K., Ikoma Y., Ando F., Yano M. Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids. Osteoporos. Int. 2008;19:211–219. doi 10.1007/s00198-007-0457-2. [PubMed] [CrossRef] [Google Scholar]
  30. Nabipour I., Sambrook P.N., Blyth F.M., Janu M.R., Waite L.M., Naganathan V., Handelsman D.J., Le Couteur D.G., Cumming R.G., Seibel M.J. Serum uric acid is associated with bone health in older men: A cross-sectional population-based study. J. Bone Min. Res. 2011;26:955–964. doi: 10.1002/jbmr.286. [PubMed] [CrossRef] [Google Scholar]

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