Lagochilus species and diterpenes isolated from them. ( Chiqarishga berilgan)
Keywords:
Lagochilus species, L.inebrians Bunge, Extraction, filtrationAbstract
Lagohilus is a very common and promising medicinal plant. All over the world, extracting substances with high biological activity from the composition of plants and creating new medicines based on them is developing rapidly. Natural compounds isolated from the composition of plants have high biological activity, and their use in medical practice and folk economy occupies a special place. The main active ingredient of the Lagoxilus plant is the diterpenoid lagoxilin, which is a four-atom alcohol. Therefore, most plants belonging to the genus Lagochilus have hemostatic properties.
References
Т.И.Цукерваник. Система рода Lagochilus (Lamiaceae). Ботанический журнал. 1985г. Т. 70.с.1183-1190.
Tskervanik, T.I. System of the genus Lagochilus (Lamiaceae). Bot. Zhurnal. 1985, 70, 1183–1190
Акопов И.Е. «Важнейшие лекарственные растения и их применение», «Медицина» УзССР 1986. 422-425.
Mamedov, N.A.; Egamberdieva, D. Phytochemical components and pharmacological effects of licorice: a review. Plant and human health; Springer International Publishing: Cham, Switzerland, 2019; Volume 3, pages 1–21. ISBN 9783030044084.
Шомуродов, X.Ф.; Ахмедов, А .; Сарибаева, С.Ю. Распространение и современное состояние Lagochilus acutilobus (Lamiaceae) в связи с развитием нефтегазовой отрасли Узбекистана. Экол. Квест. 2014, 19, 45–49, doi: 10.12775 / EQ.2014.004.
Красная книга Республики Узбекистан. Заводы (Ташкент: Чинор ЭНК) 2009, 1, 256.
Chjan, M.L.; Zeng, X.Q .; Sanderson, S.C .; Byalt, V.V .; Suxorukov, A.P. The concept of Central Asian flora from the Cenozoic The origin and irradiation of the Tianshan Mountains of Lagochilus (Lamiaceae). PLoS ONE 2017, 12, e0178389, doi: 10.1371 / journal.pone.0178389.
Jiang, M .; Chjao, S .; Yang, S .; Lin, X .; U, X .; Vey, X .; Song, Q .; Li, R .; Fu, C .; Chjan, J .; and others. “The main herbal medicine” is licorice: a review of phytochemicals and their effects in combination preparations. J. Ethnopharmacol. 2020, 249, 112439. [CrossRef]
Sokolov, S .; Zamotaev, I. Handbook of Medicinal Plants; Medicine: Moscow, Russia, 1985. (in Russian
The acute toxicity of the new derivatives of lagochilin was 3-5 times less than their initial components (succinic anhydride and lagoсhilin).
The most effective dose for succinates of lagochilin was a dose of 1 mg / kg, which reduced the bleeding time in rats by 3.0-4.5 times as compared to intact animals.
Flora of the USSR. M., L.: AN SSSR. 1954.
M.M. Abramov., S.A. Yaparova. // Obtaining the main active principle from the intoxicating Lagohilus // Jurn. app.
chemistry. 1963. T36. No. 11. p. 2554-2556.
N. Zainutdinov, R. Islamov, D. N. Dalimov, T. R. Abdurakhmanov,A.D.Matchanov., N. L. Vypova // Structure-activity relationship for hemostatic lagochilin diterpenoids // 38 pp. 161-163. 2002, vol.
N.S. Gulyamova, G.Yu Akmalova, A.Kh. Islomov, U.N. Zainutdinov, G. Rakhmanberdiev. // Technology of production of Lagochirzin and its sodium salt (lagoden) // Chemistry and Chemical Technology. Tashkent. 2010. No. 2, P. 35-38.
U.N. Zaynutdinov., R. Islomov, D.N. Dalimov., T.R
Abdurakhmonov., A.D Matchanov., N.L. Vypova //Structure-activity relationship for hemostatic lagochilin diterpenoids// 38 pp. 161-163. 2002, vol.
Zaynutdinov U.N, Mavlyanqulova Z.I, Aslanov, K.A. Chemical study of Lagochilus pubescens. Chemistry. Nat. Compd. 1975, 11, 287–288, doi: 10.1007 / BF00570708.
Mavlankulova Z.I, Zaynutdinov U.N, Aslanov, K.A. Lagochilus pubescens diterpenlari. Chemistry. Nat. Compd. 1977, 13, 39–41, doi: 10.1007 / BF00566167.
Islomov R, Zaynutdinov U.N, Aslanov, K.A. Lagochilin 3-monoacetate Lagochilus inebrians. Chemistry. Nat. Compd. 1978, 14, 342–343, doi: 10.1007 / BF00713342.
Nurmatova M.P, Zaynutdinov U.N, Kamaev F.G, Aslanov K.A. Structure and configuration of new diterpenoid lactone from Lagochilus hirsutissimus. Chemistry. Nat. Compd. 1979, 15, 695–699, doi: 10.1007 / BF00565564.
Рахимов Д.А, Маликова М.Х, Вахобов А.А, Рузиев И.О, Абдурахмонов Т.Р. Растительные полисахариды. Полисахариды Lagochilus и их биологическая активность. Химия. Нац. комп. 1995, 31, 260–261, doi: 10.1007 / BF01170221.
Рахимов, Д.А, Маликова, М.Х, Вахобов, А.А, Абдурахмонов, Т.Р, Розиев, О.И. Растительные полисахариды. IX. Выделение и антикоагулянтная активность полисахаридов Lagochilus usunachmaticus. Химия. Нац. комп. 1997, 33, 534–535. дои: 10.1007 / BF02254796.
Зайнутдинов, У.Н, Исламов Р. Активные вещества Lagochilus inebrians. Журнал «Хим-Фарми». 1986, 20, 583–584.
Абрамов, М.М, Япарова, С.А. Получение основного активного начала из Lagochilus inebrians. журнал Приклад. Сим. 1963, 11, 2554–2556.
Sobirova Fotima, Esanov Rakhmat, Elmurodov Laziz, Nataliya Vypova, Alimjon Matchanov Synthesis and Biological Activity of Succinates 3,15,16,18 Tetrahydroxy 9-13-Epoxylabdane International Journal of Materials and Chemistry 2020, 10(1): 8-15 DOI: 10.5923/j.ijmc.20201001.03
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
User Rights
Under the Creative Commons Attribution-NonCommercial 4.0 International (CC-BY-NC), the author (s) and users are free to share (copy, distribute and transmit the contribution).
Rights of Authors
Authors retain the following rights:
1. Copyright and other proprietary rights relating to the article, such as patent rights,
2. the right to use the substance of the article in future works, including lectures and books,
3. the right to reproduce the article for own purposes, provided the copies are not offered for sale,
4. the right to self-archive the article.
