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Abstract

The toxic effect of sunset yellow (E110) were studied in albino male rats. Twenty albino male rats mean weight (75± 2 gm) were used and divided into two equal groups: 1st group (Control) group contain (10) rats feed on healthy pellet, 2nd group (treated group) contain 10 rats’ daily intake for 120 days by gavage (2g /1 kg b.w) Sunset yellow (E110) dissolved in distal water. Biochemical analysis of serum at day 60 & 120 of experimental by analysis catalase (Iu/mg), Malonaldehyde (MDA) (mol/L), serum Alanine transaminase (ALT) and Aspartate transaminase (AST)(Iu/l). Liver tissue were taken for histopathology changes at days (120) and stained by H&E and masson trichrome. Result showed significant decrease P


<0.05 in catalase & significant increase in MDA, ALT &AST in treated group at 60 & 120 days. Liver cirrhosis & granuloma with necrosis is the most impudent lesion in treated group.>

Keywords

Liver Cirrhosis Granuloma Food

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How to Cite
Ahmed Abdullah Sultan. (2022). Liver Cirrhosis in Albino Male Rats Induced by Sunset Yellow (E110) Dyes. Texas Journal of Agriculture and Biological Sciences, 5, 71–77. Retrieved from https://zienjournals.com/index.php/tjabs/article/view/1987

References

  1. Al-Kaisei, B. I., Humadi, A., & Humadai, T. J. (2019). TOXICOPATHOLOGICAL AND MUTAGENIC OF FOOD DYES SUNSET YELLOW (E-110) ON WISTER MALE RATS. Biochemical and Cellular Archives, 19(2), 3421-3426.
  2. Antakli, S. A. A. D., Nejem, L. E. O. N., & Katran, S. H. E. R. E. N. (2015). Simultaneous determination of Tartrazine and Brilliant Blue in foodstuffs by spectrophotometric method. International Journal of Pharmacy and Pharmaceutical Sciences, 7, 214-218.‏
  3. Kunkel, E. M., & Barbara, H. D. (2004). Gale Nutrition and Well-being A to Z. The Gale Group Inc., Macmilln Refernce USA, New York.‏
  4. Daniel M. (2007) Reactions to food Additives and preservatives Drug adminstration 131.
  5. Weiss, B. (2010). Neurobehavioral Effects of Artificial Food Dyes, with Bernard Weiss. Podcasts: The Researcher's Perspective, 2010(1).‏
  6. Feng, J., Cerniglia, C. E., & Chen, H. (2012). Toxicological significance of azo dye metabolism by human intestinal microbiota. Frontiers in bioscience (Elite edition), 4, 568.
  7. Yadav, A., Kumar, A., Dwivedi, P. D., Tripathi, A., & Das, M. (2012). In vitro studies on immunotoxic potential of Orange II in splenocytes. Toxicology letters, 208(3), 239-245.‏
  8. Curran, L. (2010). Food Dyes Linked to Cancer, ADHD, Allergies. Food safety news.‏
  9. Choi, H. (2012). Risk assessment of daily intakes of artificial colour additives in food commonly consumed in Korea. Journal of Food and Nutrition Research, 51(1), 13-22.‏
  10. Hadwan, M. H., & kadhum Ali, S. (2018). New spectrophotometric assay for assessments of catalase activity in biological samples. Analytical biochemistry, 542, 29-33.‏
  11. Buege, J. A., & Aust, S. D. (1978). [30] Microsomal lipid peroxidation. In Methods in enzymology (Vol. 52, pp. 302-310). Academic press.‏
  12. Suvarna, K. S., Layton, C., & Bancroft, J. D. (Eds.). (2018). Bancroft's theory and practice of histological techniques E-Book. Elsevier health sciences.
  13. Morgan, G. A., Barrett, K. C., Leech, N. L., & Gloeckner, G. W. (2019). IBM SPSS for Introductory Statistics: Use and Interpretation: Use and Interpretation. Routledge.‏
  14. Khayyat, L. I., Essawy, A. E., Sorour, J. M., & Soffar, A. (2018). Sunset Yellow and Allura Red modulate Bcl2 and COX2 expression levels and confer oxidative stress-mediated renal and hepatic toxicity in male rats. PeerJ, 6, e5689.‏, 190 (2-3), 103-13
  15. Amin, K. A., Hameid II, H. A., & Abd Elsttar, A. H. (2010). Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food and Chemical Toxicology, 48(10), 2994-2999.‏
  16. Saxena, B., & Sharma, S. (2015). Food color induced hepatotoxicity in Swiss albino rats, Rattus norvegicus. Toxicology international, 22(1), 152.